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  4. Recombinant Mouse Platelet-derived growth factor C (Pdgfc)

Recombinant Mouse Platelet-derived growth factor C (Pdgfc)

  • 货号：
    CSB-YP817219MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP817219MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP817219MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP817219MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP817219MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pdgfc; Scdgf; Platelet-derived growth factor C; PDGF-C; Fallotein; Spinal cord-derived growth factor; SCDGF; VEGF-E) [Cleaved into: Platelet-derived growth factor C; latent form; PDGFC latent form); Platelet-derived growth factor C; receptor-binding form; PDGFC receptor-binding form)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-345
  • 氨基酸序列
    ESNLSSKL QLSSDKEQNG VQDPRHERVV TISGNGSIHS PKFPHTYPRN MVLVWRLVAV DENVRIQLTF DERFGLEDPE DDICKYDFVE VEEPSDGSVL GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF PSEPGFCIHY SIIMPQVTET TSPSVLPPSS LSLDLLNNAV TAFSTLEELI RYLEPDRWQV DLDSLYKPTW QLLGKAFLYG KKSKVVNLNL LKEEVKLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK VTKKYHEVLQ LRPKTGVKGL HKSLTDVALE HHEECDCVCR GNAGG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
  • 基因功能参考文献：
    1. Results provide both in vitro and in vivo evidence that Mac-1 acting together with LRP1 facilitates PDGF-CC activation by thrombolytic tissue plasminogen activator in the neurovascular unit. The requirement of both Mac-1 and LRP1 for efficient activation of PDGF-CC by tPA provides a novel mechanism that helps limit PDGFRalpha signaling in the neurovascular unit. PMID: 28725968
    2. High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. PMID: 27033449
    3. PDGF-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF-CC during renal fibrosis PMID: 26216283
    4. heme oxygenase-1 (HMOX1) activity is critically required for the vascular protective/survival effect of PDGF-CC. PMID: 25267616
    5. Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) on C57BL/6N [Crb1(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration. PMID: 24709779
    6. loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane PMID: 24046351
    7. Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes. PMID: 23856609
    8. High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma. PMID: 23929039
    9. PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 PMID: 22362252
    10. Data identified PDGF-CC as an important candidate target gene for antiangiogenic therapy, and PDGF-CC inhibition may be of therapeutic value in treating neovascular diseases. PMID: 20566880
    11. PDGF-CC is critically required for neuronal survival in both brain and retina. Its neuroprotective effect of PDGF-CC is achieved by regulating GSK3beta phosphorylation and expression. PMID: 20231377
    12. During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain PMID: 11744381
    13. Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. PMID: 12032822
    14. Data show that platelet-derived growth factor-C is a potent mitogen for cardiac fibroblasts, and overexpression results in an expansion of the interstitium that induces a secondary sex-dependent hypertrophic response in the cardiomyocytes. PMID: 12875986
    15. role for PDGF-C in bleomycin-induced pulmonary fibrosis. PMID: 12972405
    16. During mouse fetal development, PDGF C was expressed in the mesonephric mesenchyme, prefusion skeletal muscle, cardiac myoblasts, and in visceral and vascular smooth muscle. PMID: 15061151
    17. Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. PMID: 15361870
    18. PDGF-C is activated during lung development and is a potent growth factor for mesenchymal cells in vivo. PMID: 16830225
    19. These results suggest that PDGF-C signaling is a new mechanism of cleft palate induced by RA. PMID: 17066417
    20. A method for the generation of conditional knockout alleles for Pdgfc is described. PMID: 17941048
    21. PDGFC induced renal fibrosis involves PDGF-alpha receptor expressing cells and proinflammatory effects in renal interstitial fibrosis PMID: 18184860
    22. some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF-C PMID: 19111878

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  • 相关疾病：
    Involved in the development of myocarditis and subsequent fibrosis in the experimental model of coxsackievirus B3-induced chronic myocarditis.
  • 亚细胞定位：
    Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 组织特异性：
    Mainly expressed in kidney, testis, liver, heart and brain (at protein level). Highly expressed in airway epithelium, interstitial cells and alveolar macrophages in the lung of mice overexpressing IL13. Expressed in the ovaries.
  • 数据库链接：

    KEGG: mmu:54635

    STRING: 10090.ENSMUSP00000029652

    UniGene: Mm.331089