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  4. Recombinant Mouse Mothers against decapentaplegic homolog 6 (Smad6)

Recombinant Mouse Mothers against decapentaplegic homolog 6 (Smad6)

  • 中文名称：
    小鼠Smad6重组蛋白
  • 货号：
    CSB-YP021792MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Smad6重组蛋白
  • 货号：
    CSB-EP021792MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Smad6重组蛋白
  • 货号：
    CSB-EP021792MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Smad6重组蛋白
  • 货号：
    CSB-BP021792MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Smad6重组蛋白
  • 货号：
    CSB-MP021792MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Smad6; Madh6; Madh7; Msmad6; Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; Mad homolog 7; SMAD family member 6; SMAD 6; Smad6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-495
  • 氨基酸序列
    MFRSKRSGLV RRLWRSRVVP DREEGSGGGG GVDEDGSLGS RAEPAPRARE GGGCSRSEVR SVAPRRPRDA VGPRGAAIAG RRRRTGGLPR PVSESGAGAG GSPLDVAEPG GPGWLPESDC ETVTCCLFSE RDAAGAPRDS GDPQARQSPE PEEGGGPRSR EARSRLLLLE QELKTVTYSL LKRLKERSLD TLLEAVESRG GVPGGCVLVP RADLRLGGQP APPQLLLGRL FRWPDLQHAV ELKPLCGCHS FTAAADGPTV CCNPYHFSRL CGPESPPPPY SRLSPPDQYK PLDLSDSTLS YTETEATNSL ITAPGEFSDA SMSPDATKPS HWCSVAYWEH RTRVGRLYAV YDQAVSIFYD LPQGSGFCLG QLNLEQRSES VRRTRSKIGF GILLSKEPDG VWAYNRGEHP IFVNSPTLDA PGGRALVVRK VPPGYSIKVF DFERSGLLQH ADAAHGPYDP HSVRISFAKG WGPCYSRQFI TSCPCWLEIL LNNHR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
  • 基因功能参考文献：
    1. A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5). PMID: 26957275
    2. These results indicate that PRIP is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad phosphorylation, through the methylation of inhibitory Smad6 PMID: 25981537
    3. These findings suggest that TNF-alpha induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 signaling inhibitor, Smad6. PMID: 25864564
    4. The Smad6 is a novel target of Arkadia, and that Arkadia positively regulates BMP signalling via degradation of Smad6, Smad7 and c-Ski/SnoN. PMID: 25762727
    5. Smad6 inhibits non-canonical TGF-beta1 signaling by recruiting the deubiquitinase A20 to TRAF6. PMID: 24096742
    6. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis PMID: 23455153
    7. Hepcidin, Smad6 and Smad7 mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad signaling pathway. PMID: 22960056
    8. Sema7A positively regulates the production of transforming growth factor (TGF)-beta1 and Smad6 to facilitate West Nile virus pathogenesis in mice. PMID: 22896629
    9. Data show that Runx1, in conjunction with Fli1, Gata2, and Scl, directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate. PMID: 21576367
    10. JNK1 activation decreases binding of inhibitory Smad6 to the type I BMP receptor. PMID: 21542012
    11. Smad7 and Smad6 significantly promoted the differentiation of mouse embryonic stem (ES) cells into ciliated cells. PMID: 20807502
    12. Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 promoter activity and its mRNA expression PMID: 20016939
    13. These results demonstrated that overexpression of Smad6 in acini enhanced the development of pancreatic fibrosis after chronic pancreatic injury. PMID: 19823096
    14. Smad6 has no role in TGF-beta response and injury in podocytes. In contrast, Smad6 is upregulated in the mesangium in human glomerular diseases and may be involved in functions independent of TGF-beta/Smad signaling. PMID: 12397035
    15. Smad6 repressed bone morphogenetic protein-induced Id1 transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP). PMID: 14645520
    16. Smad6 transgenic mice showed postnatal dwarfism with osteopenia and inhibition of Smad1/5/8 phosphorylation in chondrocytes. PMID: 15123739
    17. Elevated intracellular cAMP might thus enhance BMP signaling by suppressing Smad6 induction and prolonging intracellular BMP signaling. PMID: 16203197
    18. OAZ can alter the intensity and duration of the BMP4 stimulus through Smad6 PMID: 16373339
    19. PRMT1 dimethylates arginine(74) (Arg(74)) in mouse Smad6. PRMT1 interacts with the N-terminal domain of Smad6 in which Arg(74) residue is located. PMID: 17118358
    20. Expression of BMP receptors Ib and II, and Smad 6 was downregulated in lungs but not kidneys of MCT-treated rats. PMID: 17347486
    21. interaction with bone morphogenetic protein type I receptors is a critical step in the function of Smad6. PMID: 17493940
    22. Data show that Smad6 expression is ubiquitous during testis development but becomes cell-specific in the adult. PMID: 18069690
    23. Pronounced changes in the expression and localization of the TGF-beta receptors Smad6 were noted as mouse lungs progressed through the canalicular, saccular, and alveolar stages of development. PMID: 18095342
    24. Smad6 facilitates the degradation of Tbx6 protein through recruitment of Smurf1. PMID: 19561075

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Dwarfin/SMAD family
  • 组织特异性：
    Ubiquitous in various organs, with higher levels in lung.
  • 数据库链接：

    KEGG: mmu:17130

    STRING: 10090.ENSMUSP00000036285

    UniGene: Mm.325757