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  4. Recombinant Mouse Metallothionein-2 (Mt2)

Recombinant Mouse Metallothionein-2 (Mt2)

  • 货号：
    CSB-YP355874MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP355874MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP355874MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP355874MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP355874MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mt2
  • Uniprot No.：
  • 别名：
    Mt2; Metallothionein-2; MT-2; Metallothionein-II; MT-II
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-61
  • 氨基酸序列
    MDPNCSCASD GSCSCAGACK CKQCKCTSCK KSCCSCCPVG CAKCSQGCIC KEASDKCSCC A
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能参考文献：
    1. these results demonstrate that MT2 plays a role in CD4+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function PMID: 27251638
    2. Metallothioneins may have a protective role against post-burn inflammation and inflammatory organ damage, at least partly through inhibiting the p38 MAPK signaling. PMID: 26833479
    3. The MT2 receptor activates Akt/GSK-3beta/CRMP-2 signaling and is necessary and sufficient to mediate functional axonogenesis and synaptic formation in central neurons. PMID: 25501601
    4. Zn deficiency in utero induces fetal epigenetic alterations of Mt2 gene and these changes are being stored as an epigenetic memory until adulthood. PMID: 22917840
    5. Knockdown of metallothionein 2 does not affect atrophy or oxidant activity in skeletal myotubes subject to serum reduction. PMID: 20798270
    6. MT-null phenotype precludes lead-induced inclusion body formation and increases lead toxicity at the organ and cellular level despite reducing lead accumulation PMID: 11891201
    7. MT-2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. PMID: 11950277
    8. In mouse spinal cord injury lead the up-regulation MT-2 expression at 1 day and MT-2 expression was observed in activated macrophages/microglia at 1 day. PMID: 15592854
    9. MT2a has a role in oxidative stress, and the formation of MT disulfide bonds is involved in the regulation of zinc homeostasis PMID: 16243847
    10. Mt-2 synthesis was induced by cilostazol. PMID: 17409522
    11. Metallothionein II deficient mice exhibit impaired rate of maze learning but retained the information as well as the wild-type mice. The absence of functional MT-II does not result in significantly worse injury following 45 min of hypoxia-ischemia. PMID: 18083145
    12. During the early phase of learning metallothionein-2 null mice were more susceptible to mercury-induced impairment compared to wildtype mice PMID: 18226494

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  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 数据库链接：

    KEGG: mmu:17750

    STRING: 10090.ENSMUSP00000034214

    UniGene: Mm.147226