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  4. Recombinant Mouse Lithostathine-1 (Reg1)

Recombinant Mouse Lithostathine-1 (Reg1)

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  • 中文名称：
    小鼠Reg1重组蛋白
  • 货号：
    CSB-EP337329MO
  • 规格：
    ￥1836
  • 促销：
    促销单品低至599元起
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Reg1
  • Uniprot No.：
  • 别名：
    Reg1; Lithostathine-1; Islet of Langerhans regenerating protein 1; REG 1; Pancreatic stone protein 1; PSP; Pancreatic thread protein 1; PTP; Regenerating protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    32.2kDa
  • 表达区域：
    22-165aa
  • 氨基酸序列
    QEAEEDLPSARISCPEGSNAYSSYCYYFTEDRLTWADADLFCQNMNSGYLVSVLSQAEGNFVASLIKESGTTDANVWTGLHDPKRNRRWHWSSGSLFLYKSWATGSPNSSNRGYCVSLTSNTGYKKWKDDNCDAQYSFVCKFKG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Might act as an inhibitor of spontaneous calcium carbonate precipitation.
  • 基因功能参考文献：
    1. These results suggest that Reg1, which is released from acinar-like cell clusters touching Langerhans islets with thin interstitial surrounding to islet beta cell clusters, has a crucial role in beta cell regeneration in ncephalomyocarditis virus-induced diabetes. PMID: 29935186
    2. Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4. PMID: 27055226
    3. Members of the Reg gene family show distinct profiles of expression in the GI tract, and Reg I independently plays a role in protecting the GI mucosa against NSAID-induced injury. PMID: 25747353
    4. Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats PMID: 24587207
    5. This study implicates the Reg1 pathway in beta-cell regeneration and describes altered programming of gene expression in low protein offspring. PMID: 23986224
    6. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
    7. Expression of Reg proteins in embryonic stem cells is modulated by Wnt/beta catenin signaling. PMID: 20050810
    8. Reg I(-/-) mice had a greater number of severe small intestinal lesions after indomethacin administration. Reg I may be useful as a therapeutic agent in NSAID-induced small intestinal injuries. PMID: 20508157
    9. transgenic overexpression of RegI (regenerating protein 1)accelerates the healing of experimental gastric ulcers. PMID: 20157293
    10. RegI and gastrin may synergistically regulate gastric mucosal proliferation during certain pathological settings like wound healing PMID: 19969026
    11. expression of the putative growth factor Reg1 is controlled through separate promoter elements by gastrin and Helicobacter. PMID: 17463184
    12. Demonstrate the presence of RegI in mouse testes. PMID: 18712671

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed only in regenerating islets and normal exocrine pancreas, but not in normal pancreatic islets. Expressed strongly in pancreas, moderately in gall bladder, and weakly in liver.
  • 数据库链接：

    KEGG: mmu:19692

    STRING: 10090.ENSMUSP00000078847

    UniGene: Mm.142731