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  4. Recombinant Mouse Iroquois-class homeodomain protein IRX-3 (Irx3), partial

Recombinant Mouse Iroquois-class homeodomain protein IRX-3 (Irx3), partial

  • 中文名称：
    小鼠Irx3重组蛋白
  • 货号：
    CSB-YP011835MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Irx3重组蛋白
  • 货号：
    CSB-EP011835MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Irx3重组蛋白
  • 货号：
    CSB-EP011835MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Irx3重组蛋白
  • 货号：
    CSB-BP011835MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Irx3重组蛋白
  • 货号：
    CSB-MP011835MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Irx3
  • Uniprot No.：
  • 别名：
    Irx3; Irxb1; Iroquois-class homeodomain protein IRX-3; Homeodomain protein IRXB1; Iroquois homeobox protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    partial
  • 表达区域：
    462-507aa
  • 氨基酸序列
    EPESGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
  • 基因功能参考文献：
    1. Irx3 is necessary for the postnatal maturation of the VCS, possibly via its interactions with Tbx5 and Nkx2.5. PMID: 26786475
    2. Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1. PMID: 24726282
    3. data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition PMID: 24646999
    4. postnatal Irx3 activity can be repressed by Irx5 PMID: 22992950
    5. Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins PMID: 21825130
    6. Irx3 signal is restricted to the somatic cell component of XX gonads and is present at a discreet period of ovarian development that ends at birth. PMID: 15963769

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 组织特异性：
    Expressed by neural progenitor cells in discrete domains of the ventral neural tube. Also expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is confi
  • 数据库链接：

    KEGG: mmu:16373

    STRING: 10090.ENSMUSP00000091002

    UniGene: Mm.238044