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  4. Recombinant Mouse Intraflagellar transport protein 80 homolog (Ift80)

Recombinant Mouse Intraflagellar transport protein 80 homolog (Ift80)

  • 中文名称：
    小鼠Ift80重组蛋白
  • 货号：
    CSB-YP815634MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ift80重组蛋白
  • 货号：
    CSB-EP815634MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ift80重组蛋白
  • 货号：
    CSB-EP815634MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ift80重组蛋白
  • 货号：
    CSB-BP815634MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ift80重组蛋白
  • 货号：
    CSB-MP815634MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ift80
  • Uniprot No.：
  • 别名：
    Ift80; Kiaa1374; Wdr56Intraflagellar transport protein 80 homolog; WD repeat-containing protein 56
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-777
  • 氨基酸序列
    MRLKISLSKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGTPV YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP LGDGKLLSHK NEISEIALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE QIIKLGTMVH TLAWCDTCNI LCGIQDTRFT VWYYPNTIYV DRDILPKTLY ERDASEYSKN PHIVSFVGNQ VTIRRADGSL VHISISPYPA ILHEYVSSSK WEEAVRLCRF VKEQSMWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN AIKDLPSRES KMAHILMFSG NIQEAETVLL QAGLVYQAIQ ININLYNWER ALELAVKYKT HVDTVLAYRQ KFLDTFGKQE TNKRYLQYAE GLQIDWEKIK AKIEMEITKE RDRSSSGQSS KSVGLKH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
  • 基因功能参考文献：
    1. IFT80 is required for osteoblast differentiation. PMID: 26996322
    2. loss of IFT80 blocks chondrocyte differentiation by disruption of ciliogenesis and alteration of Hh and Wnt signaling transduction. PMID: 26098911
    3. Silencing IFT80 impaired cilia formation and chondrogenic differentiation in mouse bone marrow derived stromal cells PMID: 23333501
    4. IFT80 plays an important role in osteogenesis through regulating Hedgehog/Gli signal pathways. PMID: 22771375
    5. an absolute requirement for Ift80 in hedgehog signalling, but low level expression permits ciliogenesis indicating separate but linked roles for this protein in formation and function. PMID: 21227999

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line.
  • 数据库链接：

    KEGG: mmu:68259

    STRING: 10090.ENSMUSP00000029347

    UniGene: Mm.389451