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  4. Recombinant Mouse Inhibitor of growth protein 1 (Ing1)

Recombinant Mouse Inhibitor of growth protein 1 (Ing1)

  • 中文名称：
    小鼠Ing1重组蛋白
  • 货号：
    CSB-YP865583MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ing1重组蛋白
  • 货号：
    CSB-EP865583MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ing1重组蛋白
  • 货号：
    CSB-EP865583MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ing1重组蛋白
  • 货号：
    CSB-BP865583MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ing1重组蛋白
  • 货号：
    CSB-MP865583MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ing1
  • Uniprot No.：
  • 别名：
    Ing1; Inhibitor of growth protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-279
  • 氨基酸序列
    MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE LDDYYEKFKR ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE NRSRQVDSHV ELFEAHQDIS DGTGGSGKAG QDKSKSEAIT QADKPNNKRS RRQRNNENRE NASNNHDHDD ITSGTPKEKK AKTSKKKKRS KAKAEREASP ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC VGLNHKPKGK WYCPKCRGES EKTMDKALEK SKKERAYNR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.
  • 基因功能参考文献：
    1. Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
    2. ING1b is an important regulator of osteoblast differentiation and suppresses PPAR-beta/delta. PMID: 26849833
    3. Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1. PMID: 24655373
    4. Study reveals a novel connection between ING1 and a regulator of microRNA biogenesis and identifies new links between tumor suppressor proteins and the microRNA machinery. PMID: 20179197
    5. Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG PMID: 11956069
    6. Characterization of nuclear localization signal in mouse ING1 homolog protein. PMID: 12054579
    7. p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras PMID: 15601862
    8. the suggested role of ing1 as a candidate tumor suppressor gene involved in control of DNA damage response. PMID: 16170338
    9. p37(Ing1) can negatively regulate cell growth and apoptosis in a p53-independent manner. PMID: 17332334
    10. Analysis of marker gene expression in p37(Ing1b)/p53 null tumors indicates that the double-null mice develop both nongerminal center and germinal center B-cell-like DLBL. PMID: 18974112

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ING family
  • 组织特异性：
    In the adult, widely expressed with highest levels in thymus and testis.
  • 数据库链接：

    KEGG: mmu:26356

    STRING: 10090.ENSMUSP00000062593

    UniGene: Mm.25709