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  4. Recombinant Mouse Glutaredoxin-1 (Glrx)

Recombinant Mouse Glutaredoxin-1 (Glrx)

  • 中文名称：
    小鼠Glrx重组蛋白
  • 货号：
    CSB-YP868752MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Glrx重组蛋白
  • 货号：
    CSB-EP868752MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Glrx重组蛋白
  • 货号：
    CSB-EP868752MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Glrx重组蛋白
  • 货号：
    CSB-BP868752MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Glrx重组蛋白
  • 货号：
    CSB-MP868752MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Glrx
  • Uniprot No.：
  • 别名：
    Glrx; Glrx1; Grx; Grx1Glutaredoxin-1; Thioltransferase-1; TTase-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-107
  • 氨基酸序列
    AQEFVNCKI QSGKVVVFIK PTCPYCRKTQ EILSQLPFKQ GLLEFVDITA TNNTSAIQDY LQQLTGARTV PRVFIGKDCI GGCSDLISMQ QTGELMTRLK QIGALQL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
  • 基因功能参考文献：
    1. These results indicate that PEP1GLRX1 attenuates neuronal cell death resulting from oxidative stress in vitro and in vivo. Therefore, PEP1GLRX1 may exhibit a beneficial role in the treatment of neuronal disorders, including ischemic injury. PMID: 29916538
    2. Data suggest an essential role of hepatic Glrx in regulating SirT1, which controls protein glutathione adducts in the pathogenesis of hepatic steatosis. PMID: 27958883
    3. Grx1 deficiency leads to eNOS dysfunction through oxidative modification of S-glutathionylation of eNOS (eNOS-SSG) and inactivation of NO production, enhancing the endothelial TLR4 activation, and ultimately exacerbating necrotizing enterocolitis severity. PMID: 26845626
    4. Our results indicate that Grx1 upregulation promotes neuroinflammation and consequent neuronal cell death in vitro, and synergizes with proinflammatory insults to promote DA loss in vivo. PMID: 27224303
    5. the Glrx1-Protein S-glutathionylation axis plays a pivotal role in house dust mite-induced allergic airways disease. PMID: 27035878
    6. Glrx ablation stabilizes HIF-1alpha by increasing GSH adducts on Cys(520) promoting in vivo HIF-1alpha stabilization, VEGF-A production, and revascularization in the ischemic muscles. PMID: 27162359
    7. Prx2 glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling. PMID: 26601956
    8. The temporal relationships of Glrx1 with protein S-glutathionylation, glutathione, and cytokines/chemokines were observed as dynamic changes in lungs with allergic airway inflammation PMID: 25874776
    9. Glutaredoxin 1 plays an important role in controlling epithelial cell responsiveness to IL-17A PMID: 24816292
    10. Up-regulated Glrx inhibits VEGF signaling by increased Flt1 causing impaired vascularization. PMID: 24482236
    11. S-glutathionylation of Fas in lung epithelium enhances epithelial apoptosis and clearance of P. aeruginosa. Glutaredoxin-1 impairs bacterial clearance and increases severity of pneumonia in association with deglutathionylation of Fas. PMID: 24325366
    12. These data suggest that the overexpression of GRX1 could protect cardiomyocytes against NO-induced apoptosis, likely through the inhibition of the oxidative modification and the nuclear translocation of GAPDH. PMID: 22846575
    13. we provide evidence that Grx1 has an important role in regulating cigarette smoke-induced lung inflammation which seems to diverge from its effects on total PSSG. PMID: 22723915
    14. results are the first to demonstrate that Grx-1 induces angiogenesis and diminishes ventricular remodeling apparently through neovascularization mediated by Akt, VEGF, Ang-1 and NF-kappaB as well as Bcl-2 and survivin-mediated anti-apoptotic pathway PMID: 22523530
    15. This result signifies that the presence of the gene allows a 1.3 times longer in vivo exposure to UVR, at equivalent irradiance, than the absence of the gene before early-onset. PMID: 22167097
    16. These results showed that cigarette smoke can modulate glutaredoxin 1, not only at the expression level, but can also directly modify glutaredoxin 1 itself, decreasing its activity. PMID: 21454804
    17. gene activation is positively regulated by NF-kappaB PMID: 21762778
    18. Grx1 regulates the production of inflammatory mediators through control of S-glutathionylation-sensitive signaling pathways. PMID: 20539014
    19. knock-outs display attenuated cardiovascular hypertrophy and oxidant generation in response to angiotensin II infusion PMID: 20638471
    20. Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines PMID: 20538586
    21. targeted disruption of Glrx1 regulates the lung proinflammatory response via histone acetylation specifically by activation of IKKalpha in response to cigarette smoke exposure. PMID: 20472709
    22. Glrx-1 gene therapy seems to prevent cardiac complications in diabetic heart due to the I/R by switching the death signal into survival signal by activating Akt-FoxO-signaling network. PMID: 20182516
    23. these findings strongly suggest that TGF-beta1 promotes epithelial-mesenchymal transition by increasing intracellular ROS levels via down-regulation of the Grx1 gene in EpRas cells. PMID: 19968960
    24. Constitutive expression of glutaredoxin 1 is higher in female mice than in males. Glutaredoxin expression is regulated via estrogen receptor signaling. Higher glutaredoxin may contribute to the neuroprotection seen in female mice exposed to neurotoxins. PMID: 15132975
    25. These findings demonstrate the physiological relevance of the S-glutathionylation-Glutaredoxin redox module in controlling the magnitude of activation of the NF-kappaB pathway. PMID: 16916935
    26. Sensitization and challenge of C57BL/6 mice with ovalbumin resulted in increased expression of GRX1 mRNA, as well as increased amounts of GRX1 protein and total GRX activity in the lung. PMID: 16980552

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Glutaredoxin family
  • 数据库链接：

    KEGG: mmu:93692

    STRING: 10090.ENSMUSP00000022082

    UniGene: Mm.25844