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  4. Recombinant Mouse Endothelin-converting enzyme 1 (Ece1), partial

Recombinant Mouse Endothelin-converting enzyme 1 (Ece1), partial

  • 中文名称：
    小鼠Ece1重组蛋白
  • 货号：
    CSB-YP700051MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ece1重组蛋白
  • 货号：
    CSB-EP700051MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ece1重组蛋白
  • 货号：
    CSB-EP700051MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ece1重组蛋白
  • 货号：
    CSB-BP700051MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ece1重组蛋白
  • 货号：
    CSB-MP700051MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ece1
  • Uniprot No.：
  • 别名：
    Ece1Endothelin-converting enzyme 1; ECE-1; EC 3.4.24.71
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts big endothelin-1 to endothelin-1.
  • 基因功能参考文献：
    1. The cardiac expression of prepro-endothelin-1 mRNA, endothelin-converting enzyme-1 mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight PMID: 25181417
    2. identify the neural peptidase ECE-1 as a negative regulator of itch on sensory nerves by directly regulating ET-1-induced pruritus PMID: 24812665
    3. differences in hemodynamic adn ece1 expression between HcB-8 and HcB-23 arteries PMID: 23699715
    4. involved in the physiological degradation of atrial natriuretic peptide PMID: 22972025
    5. Ece1 is necessary for regression of the cranial arch arteries and growth of the most caudal arch arteries. PMID: 12950083
    6. Our results provide evidence of structural conservation of mammalian genes encoding ECE-1 and will facilitate a more refined analysis of ECE-1 mRNA expression in the mouse model organism. PMID: 16540265
    7. increased neuronal PKCepsilon activity can promote Abeta clearance and reduce AD neuropathology through increased endothelin-converting enzyme activity PMID: 16698938
    8. beta-amyloid levels in the brain are regulated by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme PMID: 16912050
    9. reduced levels of endothelin converting enzyme-1 mRNA in the male mouse bowel at the time that enteric nervous system precursors migrate into the colon PMID: 17131407
    10. diabetes and contrast media increased tubular and endothelial cell eCE1, particularly in the medulla PMID: 18385664
    11. Overexpression of endothelin-converting enzyme reduces Abeta deposits in amyloid precursor protein plus presenilin-1 transgenic mice PMID: 18665160
    12. These data support a critical role for the ECE-1/ET-1 system in inflammation-associated premature delivery. PMID: 18772340
    13. ECE-1 increases in different atherosclerosis situations. Up-regulation of ECE-1 could contribute, at least partially, to the development of hypertension seen in apoE-deficient mice. PMID: 18997155
    14. Ece1 is the gene responsible for Bmd7 and it acts by increasing responsiveness to mechanical loading through modulation of Wnt signaling. PMID: 19261723

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase M13 family
  • 数据库链接：

    KEGG: mmu:230857

    STRING: 10090.ENSMUSP00000099576

    UniGene: Mm.401062