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  4. Recombinant Mouse D (1A) dopamine receptor (Drd1), partial

Recombinant Mouse D (1A) dopamine receptor (Drd1), partial

  • 中文名称：
    小鼠Drd1重组蛋白
  • 货号：
    CSB-YP713981MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Drd1重组蛋白
  • 货号：
    CSB-EP713981MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Drd1重组蛋白
  • 货号：
    CSB-EP713981MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Drd1重组蛋白
  • 货号：
    CSB-BP713981MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Drd1重组蛋白
  • 货号：
    CSB-MP713981MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Drd1; Drd1a; Gpcr15D(1A) dopamine receptor; Dopamine D1 receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能参考文献：
    1. D1/D2 medium spiny neurons in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease. PMID: 28128287
    2. These results suggested that D1R has versatile functions, and the knockdown timing greatly influences the normal motor activity in the adolescent to adult stages. PMID: 29183706
    3. Heroin-induced impulsive behavior in the 5-choice serial reaction time task is oppositely modulated by D1 and D3 receptor activation. PMID: 27815417
    4. This study explored the spatial distribution of D1 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D1-tdTomato double transgenic mice. PMID: 28860974
    5. Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine. PMID: 28115704
    6. Study indicates that dopamine D1Rs are expressed by different classes of interneurons in all layers examined and not by pyramidal cells, suggesting that hippocampus CA1 D1R mostly acts via modulation of GABAergic interneurons. PMID: 27678395
    7. Findings show that dopamine D1/5 receptor activation is a target for the enhancement of fear or reward extinction. PMID: 26763483
    8. Study shows that dopamine and the dopamine receptor D1 are associated with decreased social interaction PMID: 28202411
    9. Study shows that suppression of striatal dopamine D1 receptors selectively impaired reward-associative learning whereas punishment-associative learning, aversion-motivated learning, and appetitive motivation were spared PMID: 28143767
    10. Dopamine D1 receptor-expressing cells in the hippocampus contribute to cocaine conditioned place preference extinction. PMID: 29089442
    11. Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats. PMID: 28429261
    12. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration PMID: 27460988
    13. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane. PMID: 28582422
    14. dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury. PMID: 27733575
    15. The result of this study showed that Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina. PMID: 26587737
    16. These data suggest that D2 MSNs and specific circuits within the basal ganglia are preferentially vulnerable to HIV-1. PMID: 28473642
    17. Resulting dopamine receptors (D1-to-D3) ratio indicates a strong upregulation of D1R-mediated pathways in old animals, which is particularly pronounced in the lumbar spinal cord. PMID: 26561599
    18. Data provides evidence that forebrain D5R activation plays a unique role in spatial learning and memory in conjunction with D1R activation PMID: 26174222
    19. Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents PMID: 26256420
    20. reveal differential roles of dopamine D1 receptor - and dopamine D2 receptor -containing accumbal shell neurons in the development of behavioral sensitization to psychostimulants PMID: 26442961
    21. Findings suggest that dopamine D1 receptor stimulation or stress weakens prefrontal cortex function via opening of hyperpolarization-activated cyclic nucleotide-gated channels at network synapses. PMID: 25731884
    22. Results suggest that D1 receptor-mediated dopaminergic transmission maintains the information flow through the direct pathway to appropriately release motor actions. PMID: 26443442
    23. Data indicate the responses of dopamine receptors D1- and D2-type medium spiny neurons (MSNs) in nucleus accumbens (NAc) to acute cocaine and during the formation of context-reward association. PMID: 26831103
    24. long-term memory consolidation depends on local D1/5 receptor signaling. PMID: 26807952
    25. psychostimulants induce downregulation of DRD1a and DRD2 mRNA expression and upregulation of tyrosine hydroxylase protein expression in the testis PMID: 26560700
    26. The first alcohol drink triggers activation of dopamine D1 receptor in nucleus accumbens. PMID: 26791202
    27. cAMP-dependent protein kinase inhibits alpha7 nicotinic receptor activity in layer 1 cortical interneurons through activation of D1/D5 dopamine receptors PMID: 25990637
    28. D1-type dopaminergic receptors are delivered to cilia by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23. PMID: 26182404
    29. results show a homeostatic, negative regulation of Galphaolf by dopamine and by D1R stimulation, which are also required for the striosomal Galphaolf pattern. PMID: 25772224
    30. the trans-activation of TRPV1 following D1R activation may contribute to the modulation of pain signaling in nociceptive sensory neurons PMID: 26319554
    31. Findings identify a previously unrecognized mechanism essential for DRD1 initiation of hippocampal synaptic plasticity that is dependent on GHSR1a, and independent of cAMP signaling. PMID: 26590421
    32. Perinatal protein malnutrition stimulates hedonic control of eating behavior by promoting increased intake of palatable foods, possibly due to increased expression of dopamine receptor DRD1a in the ventral striatum PMID: 25933794
    33. The dopamine receptor D1 but not the D3 is also critical for morphine-induced BDNF expression. PMID: 25729949
    34. contextual fear conditioning was strongly reduced in striatum-specific dopamine D1 receptor knockout mice. striatal D1 receptor is essential for contextual fear conditioning. PMID: 24496082
    35. Results show that native D1 receptors (Drd1a) exhibit overlapping patterns of expression with tyrosine hydrolase clusters across the neonatal striatum, and are endemic to striatal patch compartment; patches also show high levels of D2 receptors (Drd2) PMID: 25556545
    36. Results suggest that D1 receptors and related signaling mechanisms play key roles in reconsolidation of cocaine memories in mice, and that these receptors may serve as novel targets for the treatment of cocaine abuse in humans. PMID: 25149631
    37. These results demonstrate that dopamine signaling to D1R-expressing neurons in the dorsal striatum plays an important role in manifestation of food anticipatory activity. PMID: 25217530
    38. Dopamine D1 receptors enhance long term potentiation induction and modulate plasticity in the medial perforant path. PMID: 25429131
    39. Our results demonstrate the ability of the D-like dopamine receptors to regulate the expression and activity of alphaA-adrenergic receptor PMID: 25339698
    40. Striatal D1-cell-ablation alone may account for the involuntary movements and locomotor, balance and orofacial deficits seen not only in Huntington disease but also in HD phenocopy syndromes with striatal atrophy. PMID: 24135007
    41. These results suggest that dentate gyrus D1Rs, but not D5Rs, contribute to the formation of distinct contextual representations of novel environments. PMID: 24843151
    42. The results demonstrated roles of dopamine D1 receptor in the activity-dependent functional development of mouse retina. PMID: 24260267
    43. LRRK2 affects the levels of dopamine receptor D1 on the membrane surface in neuronal cells PMID: 24167564
    44. the role of mu opioid, D and D dopamine ventral hippocampal (CA) receptors upon cholestasis-induced anxiolytic-like behaviors PMID: 23876451
    45. This study demonistrated that Medial prefrontal D1 dopamine neurons control food intake. PMID: 24441680
    46. Medium spiny neurons (MSNs) from the direct pathway express high levels of D1 dopamine receptors, while MSNs from the indirect pathway express high levels of D2 dopamine receptors. PMID: 23843993
    47. D1-like receptors in the prefromtal cortex enhance phosphorylation of CREB. PMID: 22456324
    48. Dopamine D1 receptor coupling to phospholipase C beta regulates forward locomotor activity. PMID: 24227722
    49. Ethanol physical dependence is regulated by D1DRs via ryanodine receptor upregulation. PMID: 23278119
    50. These results indicate that l-dopa stimulated both normal and dyskinetic movements primarily via D1 receptor activation PMID: 23357114

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:13488

    STRING: 10090.ENSMUSP00000021932

    UniGene: Mm.54161