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  4. Recombinant Mouse CREB-regulated transcription coactivator 1 (Crtc1)

Recombinant Mouse CREB-regulated transcription coactivator 1 (Crtc1)

  • 中文名称：
    Recombinant Mouse CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-YP724252MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-EP724252MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-EP724252MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-BP724252MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-MP724252MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crtc1
  • Uniprot No.：
  • 别名：
    Crtc1; Kiaa0616; Mect1; Torc1CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1 homolog; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-630
  • 氨基酸序列
    MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY YGGSLPNVNQ IGSSSVDLAF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTVYLSP PADTSWRRTN SDSALHQSTM TPSQAESFTG GSQDAHQKRV LLLTVPGMED TGAETDKTLS KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT NIHFPSPLPT PLDPEEPPFP ALTSSSSTGS LAHLGVGGAG QGMNTPSSSP QHRPAVVSPL SLSTEARRQQ AQQVSPTLSP LSPITQAVAM DALSLEQQLP YAFFTQTGSQ QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS LTRGPQLPPL SVTVPSTLPQ SPTENPGQSP MGIDATSAPA LQYRTSAGSP ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF GDAYYEQQMT ARQANALSRQ LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL QDPQQLGYTG HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP LTLDGLHMLN DPDMVLADPA TEDTFRMDRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated. Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
  • 基因功能参考文献：
    1. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity. PMID: 29217834
    2. CRTC1 selectively plays protective role against nonalcoholic fatty liver disease development.CRTC1 also mediates anti-lipogenic effects of bile acid signaling, whereas it is negatively regulated by miR-34a. PMID: 27869139
    3. the HDAC3-N-CoR corepressor complex leaves the Fgf1b promoter and a complex involving the translocated CRTC1, phosphorylated CREB, and histone acetyltransferase CBP induces transient transcription. PMID: 28076781
    4. this study shows that mTORC1 activation is required for fueling B cells prior to dark zone proliferation rather than for allowing cell-cycle progression itself and must be regulated dynamically during cyclic re-entry to ensure efficient affinity-based selection PMID: 28636954
    5. The NR2B-CREB-miR212/132-CRTC1-CREB signal network plays an important role in the regulation of pain. PMID: 28244951
    6. Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration. PMID: 27587263
    7. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response PMID: 28069808
    8. Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf and Nr4a1-2. By acting downstream of CRTC1, the HDAC inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice. PMID: 26970016
    9. Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain. PMID: 27060162
    10. This study demonstrates that TSC1- mechanistic target of rapamycin complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1] PMID: 25213336
    11. These data identify Notch as a therapeutically actionable branch point of metabolic signaling at which Akt activation in the liver can be uncoupled from hepatosteatosis.[mTORC1] PMID: 23832089
    12. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 [mTORC1] PMID: 23109424
    13. CRTC1 has a wide impact on CREB-dpendent memory processes and fine-tunes CREB output in a region-specific manner. PMID: 25277455
    14. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade. PMID: 25164809
    15. mTORC1 activity is necessary and sufficient for the transition of satellite cells from G0 into G(Alert) and that signalling through the HGF receptor cMet is also necessary PMID: 24870234
    16. Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease. PMID: 24760838
    17. Fisetin inhibits Akt-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice. PMID: 23517912
    18. Report dose-dependent suppression of mTOR activity by IL-6 and suppressed mTOR responsiveness to glucose administration in Apc(Min/+) mice. IL-6 suppression of mTOR activity was dependent on AMPK activation and independent of STAT signaling in myotubes. PMID: 23531613
    19. impaired expression and function of TORC1, which results in a reduction in PGC-1alpha, plays an important role in mitochondrial dysfunction in HD PMID: 22589249
    20. mTORC1 and Akt have different yet synergistic effects during the development of liver tumors in mice. PMID: 23376645
    21. CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation. PMID: 23447692
    22. increasing CRTC1 function is sufficient to enhance the strength of new, as well as established reactivated, memories without compromising memory quality. PMID: 23223304
    23. results suggest that denervation induces not only muscle degradation but also adaptive muscle response in a proteasome- and mTORC1-dependent manner PMID: 23209294
    24. The data of this study supported that a role for the CRTC1-CREB pathway in mood disorders etiology and behavioral response to antidepressants and identify CRTC1 as an essential coactivator of genes involved in mood regulation. PMID: 22592058
    25. Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity. PMID: 22770221
    26. Data suggest that increased activation of mTORC1 can promote carcinogenesis. PMID: 22457330
    27. The neuroprotective effect of Sirt1 requires the presence of CREB-regulated transcription coactivator 1 (TORC1), a brain-specific modulator of CREB activity. PMID: 22179316
    28. TORC1 increases the Gonadotropin-releasing hormone activation of the Follicle Stimulating Hormone promoter and works synergistically with Nur77 and/or CREB. PMID: 21986493
    29. Results indicate that CRTC1 protein is expressed in submandibular salivary gland epithelia during early stages of morphogenesis, disappears with differentiation, and reappears in initial tumor-like pathology. PMID: 20837164
    30. Data find that TORC1 activity is transiently upregulated during the endoderm-intestine transition in mouse. PMID: 20925120
    31. These findings suggest that CRTC1 plays a key role in coupling synaptic activity to gene transcription required for hippocampal-dependent memory, and that beta-amyloid could disrupt cognition by affecting CRTC1 function. PMID: 20631169
    32. mTORC1 signaling plays a major role in the integration of the mitogenic signal in follicular thyroid cancer. PMID: 20299527
    33. Effect of activation and inhibition of the mammalian TORC1 signaling pathway on the expression of adipose triglyceride lipase. PMID: 20068142
    34. Tsc1/mTORC1 signaling and PTEN/PI3K signaling synergistically regulate the dormancy and activation of primordial follicles. PMID: 19843540
    35. TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus PMID: 17360587
    36. These studies uncover a critical role for the Tsc2/mTOR pathway in regulation of beta cell mass and carbohydrate metabolism in vivo. PMID: 18587048
    37. Data suggest that mTORC1 controls translation of leptin mRNA via a novel mechanism that does not require the presence of either the 5'-terminal oligopyrimidine tract or the 5'-UTR. PMID: 18653778
    38. mTORC1 promotes survival through translational control of Mcl-1. PMID: 18664580
    39. the Creb1-Crtc1 pathway mediates the central effects of hormones and nutrients on energy balance and fertility. PMID: 18758446
    40. TSC1 is a critical regulator of hematopoietic stem cell self-renewal, mobilization, and multilineage development and executes these actions via both mTORC1-dependent and -independent pathways PMID: 19052232
    41. findings suggest that mTORC1 mediates glucose amplification of lipotoxicity, acting through activation of endoplasmic reticulum (ER) stress and JNK; mTORC1 is an important transducer of ER stress in beta-cell glucolipotoxicity PMID: 19305497
    42. Crtc1 may be required for the hypothalamic expression of genes that mediate the effects of leptin on energy balance but not on fertility. PMID: 19734865

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TORC family
  • 组织特异性：
    Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum.
  • 数据库链接：

    KEGG: mmu:382056

    STRING: 10090.ENSMUSP00000075916

    UniGene: Mm.227767