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  4. Recombinant Mouse Beta-defensin 14 (Defb14)

Recombinant Mouse Beta-defensin 14 (Defb14)

  • 中文名称：
    Recombinant Mouse Beta-defensin 14(Defb14)
  • 货号：
    CSB-EP749254MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Defb14
  • Uniprot No.：
  • 别名：
    Defb14; Beta-defensin 14; BD-14; mBD-14; Defensin; beta 14
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    21.2kDa
  • 表达区域：
    23-67aa
  • 氨基酸序列
    FLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has antibacterial activity.
  • 基因功能参考文献：
    1. this work demonstrates that mouse beta-defensin-14 can promote the maturation of dendritic cells in which TLR-4 is possibly involved PMID: 29253819
    2. This study indicated that the potential antibacterial role of increased MBD-14 in the osteomyelitis mouse model. PMID: 24489798
    3. BD14 expression by tumor-infiltrating host cells results in chemoattraction of CCR6-positive B220-positive lymphocytes, which in turn initiates a proangiogenic pathway leading to enhanced angiogenesis and organized tumor tissue development. PMID: 22504651
    4. Murine beta-defensin-14, like ultraviolet radiation (UVR), can shift surface marker expression of CD4+CD25- T cells toward a regulatory (Treg) phenotype but does not appear to play a major role in UVR-induced immunosuppression. PMID: 22174455
    5. beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants PMID: 20483750
    6. both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3. PMID: 18167348
    7. chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds PMID: 18180295

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-defensin family
  • 数据库链接：

    KEGG: mmu:244332

    STRING: 10090.ENSMUSP00000062781

    UniGene: Mm.358923