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  4. Recombinant Mouse Bcl-2-modifying factor (Bmf)

Recombinant Mouse Bcl-2-modifying factor (Bmf)

  • 中文名称：
    Recombinant Mouse Bcl-2-modifying factor(Bmf),Yeast
  • 货号：
    CSB-YP856336MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Bcl-2-modifying factor(Bmf),Yeast
  • 货号：
    CSB-EP856336MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Bcl-2-modifying factor(Bmf),Yeast
  • 货号：
    CSB-EP856336MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Bcl-2-modifying factor(Bmf),Yeast
  • 货号：
    CSB-BP856336MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Bcl-2-modifying factor(Bmf),Yeast
  • 货号：
    CSB-MP856336MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bmf
  • Uniprot No.：
  • 别名：
    BmfBcl-2-modifying factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-185
  • 氨基酸序列
    MEPPQCVEEL EDDVFQSEDG EPGTQPGGLL SADLFAQSQL DCPLSRLQLF PLTHCCGPGL RPISQEDKAT QTLSPASPSQ GVMLPCGVTE EPQRLFYGNA GYRLPLPASF PAGSPLGEQP PEGQFLQHRA EVQIARKLQC IADQFHRLHT QQHQQNRDRA WWQVFLFLQN LALNRQENRE GVGPW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in apoptosis.
  • 基因功能参考文献：
    1. In clinical Esophageal squamous cell carcinoma (ESCC)specimens, BMF expression was upregulated, and negatively correlated with that of miR-125b. In conclusion, miR-125b had an antitumor role in ESCC cells mediated by targeting BMF, which can be potentially useful for tumorigenesis in ESCC PMID: 29749531
    2. demonstrate that this sudden and dramatic loss of primordial follicles is hormonally triggered and identify the pro-apoptotic BH3-only protein, BCL-2 modifying factor (BMF), as essential for this process, implicating the intrinsic apoptotic pathway as a key mechanism. PMID: 28771225
    3. FOXO-dependent BMF expression is repressed in E-cadherin-negative and metastatic breast cancer cells and that expression of BMFis sufficient to inhibit tumour growth and dissemination in mice. PMID: 27035620
    4. BMF loss is associated with germ cell loss during oogenesis. PMID: 26917450
    5. Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf), mediate apoptosis in the context of TACI-Ig overexpression that effectively neutralizes BAFF as well as APRIL. PMID: 25698446
    6. Bmf deficiency induced significant protection against oxygen/glucose deprivation injury in cultured neurons. PMID: 25299781
    7. Our findings support an important role for BMF in determining the number of primordial follicles maintained in the ovary throughout adult reproductive life. PMID: 24571986
    8. Bim and Bmf act in concert to prevent autoimmunity and malignant disease PMID: 24632712
    9. Bmf-deficient mice showed normal sensitivity to the convulsant effects of KA, displayed significantly more neuronal death in the hippocampal CA1 and CA3 subfields after SE. PMID: 23618904
    10. deacetylation of p53 suppresses Bmf expression and facilitates autophagy. PMID: 23629966
    11. critical role for Bim and Bmf as regulators of hematopoietic stem and progenitor cell dynamics both during early engraftment and long-term reconstitution PMID: 23180554
    12. our study suggests that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation by mechanisms that may not exclusively be linked to the induction of lymphocyte apoptosis. PMID: 22430207
    13. a potential role for Bmf in regulating renal proximal tubular cells (RPTC) apoptosis and tubular atrophy in diabetes. PMID: 22210314
    14. characterization of the bmf gene locus; molecular basis of the generation of the 2 major isoforms of Bmf; provide evidence that Bmf can act as a sensor for stress that associates with the repression of the conventional CAP-dependent translation machinery PMID: 20706276
    15. Data show that loss of Bmf reduced the pressure to inactivate p53, whereas Bad deficiency did not, identifying Bmf as a novel component of the p53-independent tumor suppressor pathway triggered by c-Myc. PMID: 19965635
    16. Developmental ablation of interdigital webbing on mouse paws and normal lymphocyte homeostasis require the cooperative activity of Bim and Bmf. PMID: 19841067
    17. Study shows, using spectroscopic methods, that the BH3-only proteins Bim, Bad and Bmf are unstructured in the absence of binding partners. PMID: 16645638
    18. TGF beta-induced Bmf and Bim undergo significant expression changes, the combined effect of which is to trigger the cell death program. PMID: 16909112
    19. Bmf is a central mediator of anoikis in mammary cells and a target of oncogenes that contribute to the progression of glandular epithelial tumors PMID: 17360431
    20. Bmf plays a critical role in apoptosis signaling and can function as a tumor suppressor. PMID: 18299399

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  • 蛋白家族：
    Bcl-2 family
  • 组织特异性：
    Widely expressed with an abundant expression in pancreas, liver kidney and hematopoietic tissues.
  • 数据库链接：

    KEGG: mmu:171543

    STRING: 10090.ENSMUSP00000087686

    UniGene: Mm.210125