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  4. Recombinant Methanocaldococcus jannaschii Proteasome-activating nucleotidase (pan)

Recombinant Methanocaldococcus jannaschii Proteasome-activating nucleotidase (pan)

  • 中文名称：
    贾纳斯奇甲烷球菌pan重组蛋白
  • 货号：
    CSB-YP691239MRU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    贾纳斯奇甲烷球菌pan重组蛋白
  • 货号：
    CSB-EP691239MRU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    贾纳斯奇甲烷球菌pan重组蛋白
  • 货号：
    CSB-EP691239MRU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    贾纳斯奇甲烷球菌pan重组蛋白
  • 货号：
    CSB-BP691239MRU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    贾纳斯奇甲烷球菌pan重组蛋白
  • 货号：
    CSB-MP691239MRU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    pan
  • Uniprot No.：
  • 别名：
    pan; MJ1176; Proteasome-activating nucleotidase; PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle
  • 种属：
    Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-430
  • 氨基酸序列
    MVFEEFISTE LKKEKKAFTE EFKEEKEIND NSNLKNDLLK EELQEKARIA ELESRILKLE LEKKELEREN LQLMKENEIL RRELDRMRVP PLIVGTVVDK VGERKVVVKS STGPSFLVNV SHFVNPDDLA PGKRVCLNQQ TLTVVDVLPE NKDYRAKAME VDERPNVRYE DIGGLEKQMQ EIREVVELPL KHPELFEKVG IEPPKGILLY GPPGTGKTLL AKAVATETNA TFIRVVGSEL VKKFIGEGAS LVKDIFKLAK EKAPSIIFID EIDAIAAKRT DALTGGDREV QRTLMQLLAE MDGFDARGDV KIIGATNRPD ILDPAILRPG RFDRIIEVPA PDEKGRLEIL KIHTRKMNLA EDVNLEEIAK MTEGCVGAEL KAICTEAGMN AIRELRDYVT MDDFRKAVEK IMEKKKVKVK EPAHLDVLYR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates. In addition to ATP, is able to cleave other nucleotide triphosphates such as CTP, GTP and UTP, but hydrolysis of these other nucleotides is less effective in promoting proteolysis than ATP. Moreover, PAN by itself can function as a chaperone in vitro.
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    KEGG: mja:MJ_1176

    STRING: 243232.MJ_1176