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  4. Recombinant Human Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)

Recombinant Human Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)

  • 中文名称：
    人UFC1重组蛋白
  • 货号：
    CSB-YP897483HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UFC1重组蛋白
  • 货号：
    CSB-EP897483HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UFC1重组蛋白
  • 货号：
    CSB-EP897483HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UFC1重组蛋白
  • 货号：
    CSB-BP897483HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UFC1重组蛋白
  • 货号：
    CSB-MP897483HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UFC1
  • Uniprot No.：
  • 别名：
    CGI-126; HSPC155; Ubiquitin fold modifier conjugating enzyme 1; Ubiquitin-fold modifier-conjugating enzyme 1; UFC1; UFC1_HUMAN; Ufm1 conjugating enzyme 1; Ufm1-conjugating enzyme 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-167
  • 氨基酸序列
    MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCNQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E1-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
  • 基因功能参考文献：
    1. that UFC1 regulates survival of Osteoarthritis chondrocytes through physically association with miR-34a PMID: 27529373
    2. Autoantibodies binding to Ufc1 were found in 19 of 29 patients (66%) with active mycobacterial infections. PMID: 25213431
    3. Uba5 residues 364-404 were demonstrated to be necessary for the transthiolation of Ufm1 to Ufc1, and Uba5 381-404 was identified to be the minimal region for Ufc1 recognition PMID: 25084390
    4. UFC1 interact with the mRNA stabilizing protein HuR to increase levels of beta-catenin in hepatocellular carcinoma. PMID: 25449213
    5. NCAM140 interacts with ufc1 and its trafficking and endocytosis is upregulated in the presense of Ufm1. PMID: 24726913
    6. The structure of human Ufc1 was solved by using both NMR spectroscopy and X-ray crystallography PMID: 19101823
    7. Identification of a novel enzyme called UFC1 for Ufm1-conjugating enzyme 1. PMID: 15071506

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  • 蛋白家族：
    Ubiquitin-conjugating enzyme family, UFC1 subfamily
  • 数据库链接：

    HGNC: 26941

    OMIM: 610554

    KEGG: hsa:51506

    STRING: 9606.ENSP00000356982

    UniGene: Hs.301412