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  4. Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E)

Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E)

  • 中文名称：
    人PPP2R5E重组蛋白
  • 货号：
    CSB-YP619075HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPP2R5E重组蛋白
  • 货号：
    CSB-EP619075HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPP2R5E重组蛋白
  • 货号：
    CSB-EP619075HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPP2R5E重组蛋白
  • 货号：
    CSB-BP619075HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPP2R5E重组蛋白
  • 货号：
    CSB-MP619075HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    2A5E_HUMAN; Epsilon isoform of regulatory subunit B56 protein phosphatase 2A; PP2A B subunit B' epsilon; PP2A B subunit B' epsilon isoform; PP2A B subunit B56 epsilon; PP2A B subunit B56 epsilon isoform; PP2A B subunit isoform B''-epsilon; PP2A B subunit isoform B'-epsilon; PP2A B subunit isoform B56-epsilon; PP2A B subunit isoform PR61-epsilon; PP2A B subunit isoform R5-epsilon; PP2A B subunit PR61 epsilon; PP2A B subunit PR61 epsilon isoform; PP2A B subunit R5 epsilon; PP2A B subunit R5 epsilon isoform; PPP2R5E; Protein phosphatase 2 regulatory subunit B (B56) epsilon isoform; Protein phosphatase 2 regulatory subunit B' epsilon; Protein phosphatase 2 regulatory subunit B' epsilon isoform; Regulatory subunit B of protein phosphatase 2 epsilon isoform; Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit epsilon; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-467
  • 氨基酸序列
    SSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL LKDVPSSEQP ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI TISRGCLTEQ TYPEVVRMVS CNIFRTLPPS DSNEFDPEED EPTLEASWPH LQLVYEFFIR FLESQEFQPS IAKKYIDQKF VLQLLELFDS EDPRERDYLK TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE LLEILGSIIN GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK CVSSPHFQVA ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN PAIVALVYNV LKAFMEMNST MFDELTATYK SDRQREKKKE KEREELWKKL EDLELKRGLR RDGIIPT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能参考文献：
    1. results suggest that the PPP2R5E phosphatase may contribute to microtubule organization by stabilizing MTCL1. PMID: 27521566
    2. PP2A holoenzyme containing B56 is responsible for the dephosphorylation of gamma-H2AX and regulation of DNA repair of double strand breaks induced by camptothecin. PMID: 25772433
    3. the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells PMID: 24997345
    4. Downregulation of PPP2R5E affects the oncogenic potential of leukemic cells. PMID: 23812941
    5. identified the phosphorylation of hSgo2 by Aurora B at the N-terminal coiled-coil region and the middle region, and showed that these phosphorylations separately promote binding of hSgo2 to PP2A and MCAK PMID: 20889715
    6. The PPP2R5E gene is identified as harboring genetic variants that can affect human cancer and are possibly under evolutionary selection pressure. PMID: 19773383

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphatase 2A regulatory subunit B56 family
  • 数据库链接：

    HGNC: 9313

    OMIM: 601647

    KEGG: hsa:5529

    STRING: 9606.ENSP00000337641

    UniGene: Hs.334868