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  4. Recombinant Human SPARC-related modular calcium-binding protein 2 (SMOC2)

Recombinant Human SPARC-related modular calcium-binding protein 2 (SMOC2)

  • 货号：
    CSB-YP884462HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP884462HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP884462HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP884462HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SMOC2
  • Uniprot No.：
  • 别名：
    bA270C4A.1; bA37D8.1 (secreted modular calcium binding protein 2); bA37D8.1; dJ421D16.1 (novel thyroglobulin type 1 repeat containing protein); dJ421D16.1; MST117; MSTP117; MSTP140; Secreted modular calcium binding protein 2; Secreted modular calcium-binding protein 2; SMAP 2; SMAP-2; SMAP2; SMOC 2; SMOC-2; SMOC2; SMOC2_HUMAN; Smooth muscle associated protein 2; Smooth muscle-associated protein 2; SPARC related modular calcium binding 2; SPARC-related modular calcium-binding protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-446
  • 氨基酸序列
    QKFSALTFL RVDQDKDKDC SLDCAGSPQK PLCASDGRTF LSRCEFQRAK CKDPQLEIAY RGNCKDVSRC VAERKYTQEQ ARKEFQQVFI PECNDDGTYS QVQCHSYTGY CWCVTPNGRP ISGTAVAHKT PRCPGSVNEK LPQREGTGKT DDAAAPALET QPQGDEEDIA SRYPTLWTEQ VKSRQNKTNK NSVSSCDQEH QSALEEAKQP KNDNVVIPEC AHGGLYKPVQ CHPSTGYCWC VLVDTGRPIP GTSTRYEQPK CDNTARAHPA KARDLYKGRQ LQGCPGAKKH EFLTSVLDAL STDMVHAASD PSSSSGRLSE PDPSHTLEER VVHWYFKLLD KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDVNN DKSISVQELM GCLGVAKEDG KADTKKRHTP RGHAESTSNR QPRKQG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.
  • 基因功能参考文献：
    1. SMOC2 was highly expressed in both peritoneal and endometrioma lesions. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue. PMID: 28678915
    2. The expression of Smoc2 was significantly higher in hepatocellular carcinoma (HCC) tissues compared with corresponding non-tumor liver tissues. Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression. PMID: 28018113
    3. L1-mediated CRC progression involves the acquisition of a stem cell-like phenotype, and that SMOC-2 elevation is necessary for L1-mediated induction of more aggressive/invasive CRC properties. PMID: 25915847
    4. could not detect an association between SMOC2 gene and AMD. This study tests the candidacy of SMOC2 gene to the etiology of AMD PMID: 22964816
    5. SMOC2 SNP may play a role in autoimmune thyroid disease susceptibility as a dominant polymorphism. PMID: 23463390
    6. mutation in exon 8 of the SMOC2 gene linked to oligodontia PMID: 23317772
    7. Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects PMID: 22152679
    8. The variant rs13208776 in SMOC2 gene does not play a major role in increasing the risk of vitiligo in Jordanian Arab patients. PMID: 20965805
    9. SMOC2 is a risk locus for generalized vitiligo and perhaps other autoimmune diseases PMID: 19890347
    10. identification of gene, chromosome mapping PMID: 12741954
    11. SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors PMID: 16774925
    12. We tested association between SMOC2 polymorphisms and FEV(1) and FVC. SMOC2 might play an important role in the determination of FEV(1) and FVC PMID: 17204727
    13. Although this study specifies rat, the s studied and discussed the human gene in this study as well. PMID: 12031507

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  • 相关疾病：
    Dentin dysplasia 1 (DTDP1)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 数据库链接：

    HGNC: 20323

    OMIM: 125400

    KEGG: hsa:64094

    STRING: 9606.ENSP00000346537

    UniGene: Hs.487200