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  4. Recombinant Human Retinoic acid receptor responder protein 3 (RARRES3), partial

Recombinant Human Retinoic acid receptor responder protein 3 (RARRES3), partial

  • 中文名称：
    人RARRES3重组蛋白
  • 货号：
    CSB-YP892340HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RARRES3重组蛋白
  • 货号：
    CSB-EP892340HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RARRES3重组蛋白
  • 货号：
    CSB-EP892340HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RARRES3重组蛋白
  • 货号：
    CSB-BP892340HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RARRES3重组蛋白
  • 货号：
    CSB-MP892340HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RARRES3
  • Uniprot No.：
  • 别名：
    HRASLS4; MGC8906; RAR responsive protein TIG3; RAR-responsive protein TIG3; RARRES3; Retinic acid inducible gene 1; Retinoic acid receptor responder (tazarotene induced) 3; Retinoic acid receptor responder protein 3; Retinoid inducible gene 1 protein; Retinoid-inducible gene 1 protein; RIG 1; rig1; Tazarotene induced gene 3 protein; Tazarotene-induced gene 3 protein; TIG 3; TIG3; TIG3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Promotes keratinocyte differentiation via activation of TGM1.
  • 基因功能参考文献：
    1. RIG-I and MDA5 receptor sensing of host non-coding RNAs facilitates the cell-intrinsic immune response to Kaposi's sarcoma-associated herpesvirus infection. PMID: 30451863
    2. we observed frameshift mutations of RARRES3 in 11 cases of colorectal cancer PMID: 29496306
    3. Data demonstrate that RIG-1 is activated after mitochondrial SUMOylation by MAPL which is an essential process for the mitochondrial antiviral signaling response. PMID: 28273895
    4. Low RIG1 expression is associated with Arenaviral infections. PMID: 29669840
    5. Conclusively, these data demonstrate the MCPIP1 contributes to attenuate influenza A virus-induced host antiviral response by suppressing RIG-I expression. PMID: 28892164
    6. Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts. PMID: 28560754
    7. Identified the tumor suppressor RARRES3 as a critical target of G9a. Epigenetic silencing of RARRES3 contributed to the tumor-promoting function of G9a PMID: 28532996
    8. Results provide evidence that RIG-I as an essential mediator for influenza A virus-induced COX-2 expression. PMID: 27265729
    9. perifascicular pattern of RIG-I expression supports the diagnosis of dermatomyositis PMID: 28738907
    10. The current study establishes that hypoxia can profoundly influence the inducible RIG-I protein expression in malignant cells of both human and murine origin, whereas this phenomenon was not identified in nonmalignant cell lines or primary cells. PMID: 28468914
    11. our study demonstrates that the novel pathway lncRNA Ftx/miR-545/RIG-I promotes hepatocellular carcinoma development PMID: 26992218
    12. this review describes antiviral activities of RIG-I against influenza viruses (standing on three legs) PMID: 27318973
    13. Study uncovered a novel aspect of Rig-I in monitoring gut microbiota through regulating IgA and IL6-STAT3-dependent Reg3gamma pathway. Besides, Rig-I loss could also promote colorectal cancer progression both in the presence and absence of intestinal bacteria. PMID: 28057020
    14. a novel mechanism of pattern recognition receptor modulation by HCV and suggests a biological function of the HCV alternate reading frame in the modulation of host innate immunity PMID: 27404108
    15. this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma PMID: 28639915
    16. Foot-and-mouth disease virus Viroporin 2B antagonizes RIG-I-mediated antiviral effects by inhibition of its protein expression. PMID: 27707918
    17. Overexpression of TIG3 suppresses tumor growth in hepatocellular carcinoma PMID: 26951515
    18. miR-34a is an antioncogene in multiple tumors, in this study, RIG-I and miR-34a suppressed cell growth, proliferation, migration, and invasion in cervical cancer cells in vitro. miR-34a was validated as a new regulator of RIG-I by binding to its 3' untranslated region and upregulating its expression level. PMID: 26910120
    19. TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-kappaB. PMID: 26299329
    20. These observations highlight the importance of RIG-I signaling in anti-HIV innate immunity in macrophages, which may be beneficial for the treatment of HIV and aid in the understanding of the neuropathogenesis of HAND. PMID: 26535695
    21. Gal1 and gal3 regulate the inflammatory response in airway epithelial cells exposed to microbial neuraminidase by modulating the expression of SOCS1 and RIG1. PMID: 26355912
    22. findings provide a new insight into the molecular link between p53, protein acylation and Wnt/beta-catenin signaling whereby RARRES3 plays a pivotal role in modulating the acylation status of signaling proteins. PMID: 25361079
    23. During Crimean-Congo hemorrhagic fever virus infection, RIG-I mediated a type I interferon response via MAVS. PMID: 26223644
    24. the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death. PMID: 25871522
    25. Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. PMID: 25752576
    26. critical for the initiation of IRF-3 phosphorylation, dimerization and downstream gene expression during antiviral innate immune response PMID: 24800889
    27. RARRES3 downregulation engages metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma. PMID: 24867881
    28. MiR-545 exerts its effects in pancreatic ductal adenocarcinoma by directly targeting RIG-1 PMID: 25315416
    29. These findings argue that TIG3 is involved in the control of keratinocyte differentiation and that loss of TIG3 in transformed cells contributes to the malignant phenotype. PMID: 24599174
    30. We show that the C-terminal hydrophobic domain targets intact TIG3 to the plasma membrane, but when isolated as an independent element localizes at the mitochondria and a segment of the N-terminal hydrophilic region targets the centrosome. PMID: 24401997
    31. Low RIG1 expression is associated with testis cancer. PMID: 22960220
    32. RIG1 gene is a downstream target of p53 in cancer cell lines PMID: 22616991
    33. Data suggest that pericentrosomal localization of TIG3 is a key event that results in microtubule and microfilament redistribution and pericentrosomal organelle clustering and that leads to cancer cell apoptosis. PMID: 21858038
    34. We conclude that TG1-catalysed cross-linking, regulated by TIG3, might play an important role in the formation of neuronal tau inclusions in certain tauopathies PMID: 22009441
    35. induction of TIG3 is associated with the suppression of anchorage-independent growth in certain aerodigestive tract cancer cells PMID: 12879006
    36. TIG3 facilitates the terminal stages in keratinocyte differentiation via activation of type I transglutaminase PMID: 12928434
    37. altered RARRES3 expression may play a role in the carcinogenesis of the liver and biliary tract. PMID: 15742394
    38. identification and characterization of the functional RA response element that is responsible for the RA-mediated induction of RIG1 gene PMID: 15850806
    39. TIG3 is negatively regulated by an activated MEK-ERK signaling pathway in ovarian carcinoma. PMID: 15856468
    40. The proapoptotic and anti-RAS activities of RIG1 are primarily associated with the Golgi localization of the protein. PMID: 17196792
    41. the TIG3 N-terminal region is required for TIG3-dependent keratinocyte differentiation, and its removal converts TIG3 into a proapoptotic protein PMID: 17762858
    42. The NC domain, especially the NC motif, plays the major role in RIG1-mediated pro-apoptotic activity. The RIG1(111-123) dodecapeptide exhibited strong pro-apoptotic activity and has potential as an anticancer drug. PMID: 19245694
    43. The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles. PMID: 19615464

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    H-rev107 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 9869

    OMIM: 605092

    KEGG: hsa:5920

    STRING: 9606.ENSP00000255688

    UniGene: Hs.17466