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  4. Recombinant Human Retinoic acid receptor beta (RARB)

Recombinant Human Retinoic acid receptor beta (RARB)

  • 中文名称：
    人RARB重组蛋白
  • 货号：
    CSB-YP019339HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RARB重组蛋白
  • 货号：
    CSB-EP019339HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RARB重组蛋白
  • 货号：
    CSB-EP019339HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RARB重组蛋白
  • 货号：
    CSB-BP019339HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RARB重组蛋白
  • 货号：
    CSB-MP019339HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RARB
  • Uniprot No.：
  • 别名：
    HAP; HBV-activated protein; NR1B2; Nuclear receptor subfamily 1 group B member 2; RAR B; RAR beta; RAR epsilon; RAR-beta; RAR-epsilon; RARB; RARB_HUMAN; Retinoic acid receptor beta 2; Retinoic acid receptor beta 4; Retinoic acid receptor beta 5; Retinoic acid receptor beta; Retinoic acid receptor beta polypeptide; RRB2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-455
  • 氨基酸序列
    MTTSGHACPV PAVNGHMTHY PATPYPLLFP PVIGGLSLPP LHGLHGHPPP SGCSTPSPAT IETQSTSSEE LVPSPPSPLP PPRVYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM IYTCHRDKNC VINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKETS KQECTESYEM TAELDDLTEK IRKAHQETFP SLCQLGKYTT NSSADHRVRL DLGLWDKFSE LATKCIIKIV EFAKRLPGFT GLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA GFGPLTDLVF TFANQLLPLE MDDTETGLLS AICLICGDRQ DLEEPTKVDK LQEPLLEALK IYIRKRRPSK PHMFPKILMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGH EPLTPSSSGN TAEHSPSISP SSVENSGVSQ SPLVQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
  • 基因功能参考文献：
    1. Hypermethylation of RARB gene is associated with high grade lung cancer. PMID: 29851970
    2. RAR-beta expression state is one of the independent factors for the prognosis of lung squamous cell carcinoma patients PMID: 29077166
    3. Although studies reported different rates for RAR beta promoter methylation in prostate can tissues, the total meta-analysis demonstrated that RAR beta promoter methylation may be correlated with prostate cancer carcinogenesis and that the RAR beta gene is particularly susceptible. PMID: 29554659
    4. Hypermethylation frequency of CpG islands in the promoters of retinoic acid receptor beta gene (RAR-beta) gene was respectively 61 and 33% for diffuse and intestinal type n gastric cancer tissues. PMID: 28759951
    5. There were significant associations between RARB promoter hypermethylation and Oral Cancer risk. PMID: 29538221
    6. Results indicate that RARbeta hypermethylation correlates well with an increased risk in non-small cell lung cancer (NSCLC) patients. RARbeta gene inactivation caused by RARbeta methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. [review] PMID: 28008143
    7. retinoic acid receptor beta-retinoic X receptor alpha heterodimer quaternary architecture variable PMID: 29021580
    8. Data shows that miR-106a directly targets RARB 3'-UTR and the miR-106a-RARB complex promotes the viability of thyroid cancer. PMID: 27342319
    9. Study identified a novel mutation in RARB gene in patients with intellectual disability and progressive motor impairment which confers gain-of-function further promoting the retinoic acid (RA) ligand-induced transcriptional activity by twofold to threefold over the wild-type receptor. These results providing novel insight into the role of RA in neural networks in humans. PMID: 27120018
    10. mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed. PMID: 27670690
    11. RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings. PMID: 28639889
    12. Upregulation of RARB enhances the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents in vitro. PMID: 27599527
    13. Lack of RARbeta nuclear expression is associated with Non-small cell lung cancer development and associated with a worse prognosis. PMID: 27306217
    14. methylated promoters of DAPK1 combined with MGMT, MGMT combined with RARB, DAPK1 combined with RARB were positive correlated with cervical disease grade PMID: 26823825
    15. Overexpression of miR-146a-5p and miR-146b-5p caused a 31% and 33% decrease in endogenous RARB mRNA levels. PMID: 27011326
    16. shows that RAR-beta methylation detected in lung tissue may be used as a predictive marker for non-small cell lung cancer diagnosis and that APC methylation in tumor sample may be a useful marker PMID: 26681652
    17. RARbeta2 methylation is significantly increased in breast cancer samples when compared to non-cancerous controls PMID: 26451736
    18. Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders. PMID: 26352270
    19. Hypermethylation at promoters of RARB, Dietary folate and cobalamin intake is inversely associated with methylated RARB and BRCA1. High dietary intake of riboflavin and pyridoxine is associated with increased methylation in the RARB promoter. PMID: 25805039
    20. Hypermethylation of RARB was associated with esophageal squamous cell carcinoma. PMID: 25514805
    21. Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis PMID: 25970467
    22. Methylated APC and RARbeta2 genes might be valuable serum-based molecular markers for early detection of breast cancer. PMID: 25684670
    23. Curcumin upregulates RARbeta by inhibiting DNMT3b expression which reverses RARbeta promoter methylation. PMID: 25981383
    24. revealed that HSP70 could directly regulate retinoid acid (RA)-induced retinoid acid receptor beta2 (RARbeta2) gene transcription through its binding to chromatin, with R469me1 being essential in this process PMID: 26080448
    25. Methylation of the RAR-beta gene with cigarette smoking is associated with non-small cell lung cancer. PMID: 25605205
    26. Data indicate a differential sensitivity of chondral versus endochondral differentiation pathways to retinoic Acid receptor-Beta (RARbeta) signaling. PMID: 24851851
    27. RAR-beta, whereas ATRA alone had no effect on methylation. The RAR-beta gene was reexpressed following DAC-ATRA combination treatment, and both agents had no effect on p16 expression. PMID: 25413479
    28. in the absence of retinoid signaling via RARbeta, reduced IGF-1 signaling results in suppression of epithelial-mesenchymal transition and delays tumorigenesis induced by the Wnt1 oncogene PMID: 25422594
    29. promoter methylation may play an important role in carcinogenesis of the NSCLC. PMID: 24796328
    30. RARbeta2 circulating DNA in lung cancer patients is at greater methylation rate than in healthy donors. PMID: 25110096
    31. The total frequency of FHIT, RASSF1A and RARbeta gene methylation was significantly higher in lung cancer. PMID: 25040980
    32. Analysis indicates that the genes BIRC5, HOXA1 and RARB are critical targets that play an important regulatory role in cervical cancer pathogenesis. PMID: 25069511
    33. Our meta-analyses identified strong associations of four aberrantly methylated genes (GSTP1, RASSF1, p16, and RARB) with Prostate cancer PMID: 25053593
    34. Results suggest that epigenetic alterations of P16INK4A (p16) and retinoic acid receptor beta (RAR-beta) have an important role in ovarian carcinogenesis. PMID: 24913706
    35. RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. PMID: 24414001
    36. RARbeta promoter is hypermethylated in all studied prostate tumors and methylation levels are positively correlated with H3K27me3 enrichments. PMID: 24492483
    37. These results highlight the relevance of MSK1 in the up-regulation of RARbeta by prostaglandin E2. PMID: 24953041
    38. The data suggest that RARbeta and p14ARF may be linked in a signaling pathway that is operating in melanocytic cells and is lost in the majority of melanomas. PMID: 23851445
    39. Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms PMID: 23969901
    40. Both recessive and dominant mutations in RARB cause anophthalmia. PMID: 24075189
    41. RARbeta2 methylation is associated with the risk of developing prostate cancer. (Meta-analysis) PMID: 23675444
    42. The highest loss of heterozygosity and/or microsatellite imbalance is revealed in RARB locus in non-small cell lung cancer. PMID: 23504373
    43. HHIP, HDAC4, NCR3 and RARB polymorphisms may have a role in impaired lung function that begins in early life PMID: 23456936
    44. All-trans retinoic acid inhibits human scleral fibroblasts proliferation by a mechanism associated with modulation of ERK 1/2 and JNK activation and depends on stimulation of retinoic acid receptor beta. PMID: 23946634
    45. Methylation of the RARB gene increases prostate cancer risk in black Americans. PMID: 23376149
    46. EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha PMID: 23644172
    47. Data show that TLR3 activation by poly I-C induces up-regulation of microRNA-29b, -29c, -148b, and -152 targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta). PMID: 23716670
    48. findings showed that hepatitis C virus Core induced promoter hypermethylation of RAR-beta2 to inhibit its expression; accordingly, Core-expressing cells exhibited resistance to ATRA-induced growth inhibition PMID: 23474497
    49. Second RARbeta2 loss of expression was found associated with different epigenetic profiles in LNCaP and DU145 cells. PMID: 23299856
    50. HIF-1alpha up-regulation is dependent on intracrine PGE2-RARbeta signalling. PMID: 22964004

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  • 相关疾病：
    Microphthalmia, syndromic, 12 (MCOPS12)
  • 亚细胞定位：
    Nucleus. Cytoplasm.; [Isoform Beta-1]: Nucleus.; [Isoform Beta-2]: Nucleus.; [Isoform Beta-4]: Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 组织特异性：
    Expressed in aortic endothelial cells (at protein level).
  • 数据库链接：

    HGNC: 9865

    OMIM: 180220

    KEGG: hsa:5915

    STRING: 9606.ENSP00000332296

    UniGene: Hs.543218