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  4. Recombinant Human Ras-related and estrogen-regulated growth inhibitor (RERG)

Recombinant Human Ras-related and estrogen-regulated growth inhibitor (RERG)

  • 中文名称：
    人RERG重组蛋白
  • 货号：
    CSB-YP850254HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RERG重组蛋白
  • 货号：
    CSB-EP850254HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RERG重组蛋白
  • 货号：
    CSB-EP850254HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RERG重组蛋白
  • 货号：
    CSB-BP850254HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RERG重组蛋白
  • 货号：
    CSB-MP850254HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RERG
  • Uniprot No.：
  • 别名：
    MGC15754 ; RAS like estrogen regulated growth inhibitor ; Ras related and estrogen regulated growth inhibitor ; Ras-related and estrogen-regulated growth inhibitor; Rerg; RERG_HUMAN; Weakly similar to N ras protein [H.sapiens]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-199
  • 氨基酸序列
    MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
  • 基因功能参考文献：
    1. this study shows that miR-382-5p expression is negatively correlated with RERG expression, and functions as an independent oncomiR for the higher incidence and poorer prognosis of breast cancer PMID: 27705918
    2. Estradiol estrogen receptor-beta and PGE2 integrate at RERG, leading to increased endometriotic cell proliferation. PMID: 24992181
    3. Results describe the mRNA expression of CRABP1, RERG, and GRP in pituitary adenomas. PMID: 21270509
    4. Loss of RERG expression is associated with breast cancer and distant metastasis. PMID: 20697807
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of
  • 数据库链接：

    HGNC: 15980

    OMIM: 612664

    KEGG: hsa:85004

    STRING: 9606.ENSP00000256953

    UniGene: Hs.199487