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  4. Recombinant Human Leiomodin-1 (LMOD1)

Recombinant Human Leiomodin-1 (LMOD1)

  • 中文名称：
    人LMOD1重组蛋白
  • 货号：
    CSB-YP013013HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LMOD1重组蛋白
  • 货号：
    CSB-EP013013HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LMOD1重组蛋白
  • 货号：
    CSB-EP013013HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LMOD1重组蛋白
  • 货号：
    CSB-BP013013HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LMOD1重组蛋白
  • 货号：
    CSB-MP013013HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LMOD1
  • Uniprot No.：
  • 别名：
    1D; 64 kDa autoantigen 1D; 64 kDa autoantigen 1D3; 64 kDa autoantigen D1; 9530015K06Rik; D1; Leiomodin; Leiomodin-1; Lmod1; LMOD1_HUMAN; muscle form; SM LMOD; SM-Lmod; SMLMOD; Smooth muscle leiomodin; Thyroid associated ophthalmopathy autoantigen ; Thyroid-associated ophthalmopathy autoantigen
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-600
  • 氨基酸序列
    MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKQST GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN GEERGRDASK KALGPRRDSD LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE RAVATKKEEE KKGSDRNTGL SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK RAGGNTDMKK EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR FTEALEFNTV VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT GKGILAIFRA LLQNNTLTEL RFHNQRHICG GKTEMEIAKL LKENTTLLKL GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ EQRQAQEAKG EKKDLLEVPK AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP LAPPLIMENL KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates nucleation of actin filaments.
  • 基因功能参考文献：
    1. Loss of LMOD1 results in a reduction of filamentous actin, elongated cytoskeletal dense bodies, and impaired intestinal smooth muscle contractility. PMID: 28292896
    2. Key role for miR-214 in modulation of MEF2C-MYOCD-LMOD1 signaling. PMID: 27144530
    3. Lmod1 is a new SMC-restricted SRF/MYOCD target gene. PMID: 22157009
    4. Lmod1 is a component of the smooth muscle contractile apparatus extractable by high salt, not a transmembrane protein as previously predicted. PMID: 11350761
    5. Lmod1, formerly the 64kD human autoantigen D1, is expressed in smooth muscle and striated extraocular slow muscle fibers, colocalized with myosin in the contractile apparatus. Protein levels are unaltered by hyperthyroidism. PMID: 10520227
    6. Lmod1 is a member of the Tropomodulin family of actin binding proteins, and is most highly expressed in smooth muscle. PMID: 11318603

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tropomodulin family
  • 组织特异性：
    Detected in lung vascular smooth muscle (at protein level). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle. Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine.
  • 数据库链接：

    HGNC: 6647

    OMIM: 602715

    KEGG: hsa:25802

    STRING: 9606.ENSP00000356257

    UniGene: Hs.519075