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  4. Recombinant Human Juxtaposed with another zinc finger protein 1 (JAZF1)

Recombinant Human Juxtaposed with another zinc finger protein 1 (JAZF1)

  • 中文名称：
    人JAZF1重组蛋白
  • 货号：
    CSB-YP803132HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人JAZF1重组蛋白
  • 货号：
    CSB-EP803132HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人JAZF1重组蛋白
  • 货号：
    CSB-EP803132HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人JAZF1重组蛋白
  • 货号：
    CSB-BP803132HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人JAZF1重组蛋白
  • 货号：
    CSB-MP803132HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    JAZF1
  • Uniprot No.：
  • 别名：
    JAZF zinc finger 1 ; JAZF1; JAZF1_HUMAN; Juxtaposed with another zinc finger protein 1; TAK1 interacting protein 27; TAK1-interacting protein 27; TIP27 ; Zinc finger protein 802; ZNF802
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-243
  • 氨基酸序列
    MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL QQPTYVALSY INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP PRHSSGSLTP PVTPPITPSS SFRSSTPTGS EYDEEEVDYE ESDSDESWTT ESAISSEAIL SSMCMNGGEE KPFACPVPGC KKRYKNVNGI KYHAKNGHRT QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEIIRK MQQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity.
  • 基因功能参考文献：
    1. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15x10-5, OR=5.07), rs16861329 on 3q27.3 (P=2.02x10-4, OR=0.87) and rs849135 on 7p15.1 (P=6.59x10-9, OR=1.78), which suggested PTPN22, ST6GAL1 and JAZF1 as novel susceptibility genes for psoriasis in Chinese population. PMID: 28603863
    2. PNPLA3 and JAZF1 were associated with non-hepatitis B virus and non-hepatitis C virus-related hepatocellular carcinoma development among Japanese patients with type 2 diabetes mellitus PMID: 26337813
    3. study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1, and rs35767 in IGF1 might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population PMID: 25785549
    4. genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated. PMID: 25596907
    5. In African American men, the association between JAZF1 rs10486567 and prostate cancer may be modified by exposure to heavy metals such as Pb. PMID: 24801046
    6. study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis PMID: 23740937
    7. Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 and PHF1 genes were correlated with tumor category and outcome in endometrial sarcomas PMID: 22918161
    8. genetic association studies in a population in Utah: Data suggest that an SNP in JAZF1 (rs1635852) is associated with type 2 diabetes; this SNP in JAZF1 intron 1 is part of a cis-regulatory complex. PMID: 23328127
    9. This study indicates a nominal role for JAZF1 and BCL11A variants in type 2 diabetes susceptibility in African-Americans. PMID: 22113416
    10. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18372903
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20712903
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 20717903
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 20816152
    14. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20878950
    15. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20879858
    16. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) PMID: 20889853
    17. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20927120
    18. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 21068098
    19. Observational study of gene-disease association. (HuGE Navigator) PMID: 21071540
    20. Observational study of gene-disease association. (HuGE Navigator) PMID: 20546612
    21. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20690139
    22. Single-nucleotide polymorphism of rs10486567 in JAZF1 is associated with prostate cancer. PMID: 20406958
    23. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    24. Observational study of gene-disease association. (HuGE Navigator) PMID: 20406958
    25. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20450899
    26. Observational study of gene-disease association. (HuGE Navigator) PMID: 20460480
    27. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20490451
    28. The JAZF1 SNPs rs6968704 and rs10486567 were associated with decreased risk of prostate cancer but were not associated with diabetes. PMID: 19998368
    29. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 20075150
    30. Observational study of gene-disease association. (HuGE Navigator) PMID: 20161779
    31. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20203524
    32. Endometrial stromal tumors(ESTs) are genetically heterogeneous, with prevalence of JAZF1-JJAZ1 fusion highest among ESTs of classic histology. Diagnostic utility of JAZF1-JJAZ1 fusion transcript assay in ESTs may be limited to classic histologic subset. PMID: 15043312
    33. TIP27 (TAK1-interacting protein 27; sequence indentical to JAZF1) functions as a repressor of the nuclear orphan receptor TAK1/TR4. PMID: 15302918
    34. The JAZF1-JJAZ1 fusion is a frequent, although nonuniform, feature of endometrial stromal neoplasia. PMID: 17197920
    35. The JAFZ1-JJAZ1 fusion gene is present in the endometrial stromal and smooth muscle components of endometrial stromal tumors. PMID: 17667554
    36. Both benign and malignant forms of endometrial stromal tumor have the JAZF1-JJAZ1 fusion, but only the malignant form also exhibits exclusion of the unrearranged JJAZ1 allele. PMID: 18077430
    37. Study show that polymorphisms in JAZF1 were associated with type 2 diabetes risk in the studied population. PMID: 18694974
    38. predicted 684-amino acid JAZF1/PHF1 chimeric protein retained one zinc finger domain from JAZF1 and the two zinc finger domains from PHF1, and its oncogenic mechanism should be similar to that of the JAZF1/SUZ12 protein PMID: 18722875
    39. study shows normal endometrial stromal cells contain a specific chimeric RNA joining 5' exons of JAZF1 gene on chromosome 7p15 to 3' exons of JJAZ1/SUZ12 gene on chromosome 17q11; this RNA is translated into JAZF1-JJAZ1 with anti-apoptotic activity PMID: 18772439
    40. Linkage and genome-wide association analyses independently identified the JAZF1 affecting human height. PMID: 18952825
    41. The JAZF1-JJAZ1 gene fusion was not identified in any Uterine tumor resembling ovarian sex cord tumors PMID: 19542872
    42. identified five new systemic lupus erythematosus susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). PMID: 19838195
    43. Observational study of gene-disease association. (HuGE Navigator) PMID: 19933996
    44. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 19998368
    45. Observational study of gene-disease association. (HuGE Navigator) PMID: 19902474
    46. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19794065
    47. Observational study of gene-disease association. (HuGE Navigator) PMID: 19833888
    48. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 19838195
    49. Observational study of gene-disease association. (HuGE Navigator) PMID: 19862325
    50. Observational study of gene-disease association. (HuGE Navigator) PMID: 19866473

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  • 相关疾病：
    A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1.
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highest expression in testis with moderate levels in colon, placenta, prostate and ovary and low levels in brain, spleen, liver and small intestine.
  • 数据库链接：

    HGNC: 28917

    OMIM: 606246

    KEGG: hsa:221895

    STRING: 9606.ENSP00000283928

    UniGene: Hs.368944