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  4. Recombinant Human Homeobox protein Hox-D9 (HOXD9)

Recombinant Human Homeobox protein Hox-D9 (HOXD9)

  • 中文名称：
    人HOXD9重组蛋白
  • 货号：
    CSB-YP010689HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXD9重组蛋白
  • 货号：
    CSB-EP010689HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXD9重组蛋白
  • 货号：
    CSB-EP010689HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXD9重组蛋白
  • 货号：
    CSB-BP010689HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXD9重组蛋白
  • 货号：
    CSB-MP010689HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXD9
  • Uniprot No.：
  • 别名：
    homeobox D9; Homeobox protein Hox D9; Homeobox protein Hox-4C; Homeobox protein Hox-5.2; Homeobox protein Hox-D9; Hox 4.3; Hox 5.2; HOX4; HOX4C; HOXD9; HXD9_HUMAN; RP23 313J15.10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-352
  • 氨基酸序列
    MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA GVADGPAATA AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV PPPPLAASAS EPGRYVRSWM EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS GPANGRHYGI KPETRAAPAP ATAASTTSSS STSLSSSSKR TECSVARESQ GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS EPSACSDHPI PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK GD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma PMID: 26514226
    2. HoxD9 expression is regulated by histone acetylation in endothelial progenitor cells PMID: 25826494
    3. Data show that overexpressing homeobox D9 protein HOXD9 in mucinous ovarian carcinomas (MOCs)cells augmented the neoplastic phenotype PMID: 26075790
    4. The study investigates the temperature dependence of the internal motions of the lysine side-chain NH3(+) groups that form ion pairs with DNA phosphate groups in the HoxD9 homeodomain-DNA complex. PMID: 25489884
    5. Results show that melanoma patients with HOXD9 hypermethylation in lymph node metastasis had poorer disease-free and overall survival. PMID: 24014427
    6. A genome-wide array-comparative genomic hybridization (aCGH) analysis revealed global chromosomal aberration in MWCNTs-treated clones, predominantly at chromosome 2q31-32, where the potential oncogenes HOXD9 and HOXD13 are located PMID: 23984819
    7. The association between SNP of the HOXD9 gene and developmental hip dysplasia reached significance in Chinese Han females. PMID: 22520331
    8. Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. PMID: 21600039
    9. 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly PMID: 11778160
    10. findings not only indicate that the HOXD9 gene is exclusively expressed in the rheumatoid arthritis synovium but also suggest that the HOXD9 gene contributes to the pathology of rheumatoid arthritis through the fibroblast-like synoviocytes PMID: 12060849
    11. HoxD9 and Pbx1 are inappropriately expressed in most human esophageal squamous cell carcinoma. Understanding the role of Hox genes in esophageal epithelial cell carcinogenesis may not only augment early detection but also offer possiblde treatment. PMID: 15770739

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5140

    OMIM: 142982

    KEGG: hsa:3235

    STRING: 9606.ENSP00000249499

    UniGene: Hs.236646