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  4. Recombinant Human Homeobox protein Hox-D11 (HOXD11)

Recombinant Human Homeobox protein Hox-D11 (HOXD11)

  • 中文名称：
    人HOXD11重组蛋白
  • 货号：
    CSB-YP010683HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXD11重组蛋白
  • 货号：
    CSB-EP010683HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXD11重组蛋白
  • 货号：
    CSB-EP010683HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXD11重组蛋白
  • 货号：
    CSB-BP010683HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXD11重组蛋白
  • 货号：
    CSB-MP010683HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXD11
  • Uniprot No.：
  • 别名：
    Homeo box 4F; Homeo box D11; Homeobox D11; Homeobox protein Hox-4F; Homeobox protein Hox-D11; Hox-4F; HOX4; HOX4F; HOXD11; HXD11_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-338
  • 氨基酸序列
    MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. High expression of HOXD11 is associated with laryngeal squamous cell carcinoma. PMID: 27658780
    2. data show no significant difference in HOXD11, HOXD12 & HOXD13 genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD PMID: 19540081
    3. In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease sensitivity as hESCs differentiate. PMID: 20085705
    4. The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15). PMID: 11782354
    5. Our findings do not support the hypothesis that mutations in the HOXD11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations. PMID: 19255789

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5134

    OMIM: 142986

    KEGG: hsa:3237

    STRING: 9606.ENSP00000249504

    UniGene: Hs.421136