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  4. Recombinant Human Histone deacetylase complex subunit SAP30L (SAP30L)

Recombinant Human Histone deacetylase complex subunit SAP30L (SAP30L)

  • 中文名称：
    人SAP30L重组蛋白
  • 货号：
    CSB-YP888011HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SAP30L重组蛋白
  • 货号：
    CSB-EP888011HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SAP30L重组蛋白
  • 货号：
    CSB-EP888011HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SAP30L重组蛋白
  • 货号：
    CSB-BP888011HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SAP30L重组蛋白
  • 货号：
    CSB-MP888011HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SAP30L
  • Uniprot No.：
  • 别名：
    FLJ11526; FLJ23595; FLJ36497; HCV non- tructural protein 4A transactivated protein 2; HCV non-structural protein 4A-transactivated protein 2; Histone deacetylase complex subunit SAP30L; NS4ATP2; SAP30 like; sap30l; Sin3 associated protein p30 like; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like; Sin3A associated protein p30-like; SP30L_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-183
  • 氨基酸序列
    MNGFSTEEDS REGPPAAPAA AAPGYGQSCC LIEDGERCVR PAGNASFSKR VQKSISQKKL KLDIDKSVRH LYICDFHKNF IQSVRNKRKR KTSDDGGDSP EHDTDIPEVD LFQLQVNTLR RYKRHYKLQT RPGFNKAQLA ETVSRHFRNI PVNEKETLAY FIYMVKSNKS RLDQKSEGGK QLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.; Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.; Functions as transcription repressor; its activity is marginally lower than that of isoform 1.
  • 基因功能参考文献：
    1. Upon oxidative stress SAP30L undergoes the formation of two specific disulfide bonds, a vicinal Cys29-Cys30 and Cys38-Cys74, with a concomitant release of the coordinated zinc ion. The oxidized protein was shown to remain folded in solution and to bind signaling phospholipids. PMID: 26609676
    2. SAP30L, a nuclear protein, is upregulated by transforming growth factor-beta in intestinal epithelial cells PMID: 14680513
    3. transcriptional repression mediated by SAP30L can be influenced by alternative mRNA splicing PMID: 18070604
    4. findings demonstrate new functions for SAP30L and SAP30 by showing that they can associate directly with core histones as well as naked DNA PMID: 19015240
  • 亚细胞定位：
    [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Nucleus, nucleolus.; [Isoform 3]: Nucleus, nucleolus.
  • 蛋白家族：
    SAP30 family
  • 组织特异性：
    Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level). Ubiquitous; expressed in all tissues tested with highest levels in testis.
  • 数据库链接：

    HGNC: 25663

    OMIM: 610398

    KEGG: hsa:79685

    STRING: 9606.ENSP00000297109

    UniGene: Hs.592566