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  4. Recombinant Human Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1), partial

Recombinant Human Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1), partial

  • 中文名称：
    人FLVCR1重组蛋白
  • 货号：
    CSB-YP897301HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FLVCR1重组蛋白
  • 货号：
    CSB-EP897301HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FLVCR1重组蛋白
  • 货号：
    CSB-EP897301HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FLVCR1重组蛋白
  • 货号：
    CSB-BP897301HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FLVCR1重组蛋白
  • 货号：
    CSB-MP897301HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FLVCR1
  • Uniprot No.：
  • 别名：
    Feline leukemia virus subgroup C cellular receptor; Feline leukemia virus subgroup C receptor; Feline leukemia virus subgroup C receptor related protein 1; Feline leukemia virus subgroup C receptor-related protein 1; FLVC1_HUMAN; FLVCR 1; FLVCR protein; FLVCR1; hFLVCR
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.; Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.
  • 基因功能参考文献：
    1. Mutation in FLVCR1 gene is associated with Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia. PMID: 28766925
    2. Using fibroblasts and lymphoblastoid cell lines from patients with sensory neurodegeneration, we here show that the FLVCR1-mutations reduce heme export activity, enhance oxidative stress and increase sensitivity to programmed cell death. Our data link heme metabolism to sensory neuron maintenance and suggest that intracellular heme overload causes early-onset degeneration of pain-sensing neurons in humans PMID: 27923065
    3. RPS19-downregulated erythroleukemia cells show reduced FLVCR1a and FLVCR1b mRNA levels associated with heme overload. PMID: 26058344
    4. Data shows that FLVCR1a participates in the control of intestinal mucosa homeostasis by exporting the excess of de novo synthesized heme from intestinal cells. PMID: 26067085
    5. Flvcr1 regulates differentiation of erythroid progenitors by controlling intracellular heme accumulation. PMID: 25795718
    6. both HIF2alpha and ETS1 are involved in the transcriptional regulation of Flvcr1a and that HIF2alpha is absolutely required for Flvcr1a induction upon hypoxia PMID: 24576667
    7. FLVCR1b regulates erythropoiesis by controlling mitochondrial heme efflux, whereas FLVCR1a expression is required to prevent hemorrhages and edema. PMID: 23187127
    8. FLVCR1 mutants failed to fold properly in the ER, were rapidly degraded in the lysosomes, and therefore, could not export heme out of cells. Thus, accumulation of heme in FLVCR1-mutant cells could cause cellular toxicity. PMID: 22483575
    9. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. PMID: 22279524
    10. Posterior column ataxia with retinitis pigmentosa is caused by mutations in FLVCR1. PMID: 21267618
    11. relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein, was assessed in placental tissue in relation to maternal/neonatal iron status and placental iron concentration PMID: 21593354
    12. These results suggest that aberrant FLVCR1 causes a selective degeneration of a subpopulation of neurons in the retina and the posterior columns of the spinal cord via dysregulation of heme or iron homeostasis. PMID: 21070897
    13. hemopexin directly interacts with FLVCR PMID: 20610401
    14. the FLVCR gene on 1q31 is not involved in Diamond-Blackfan anemia in families studied PMID: 15996880
    15. results suggest that multiple FLVCR1 regions are critical for mediating efficient feline leukemia virus subgroup C (FeLV-C) infection and that these regions are distinct from the FeLV-C envelope binding site PMID: 16439531
    16. Alternative splicing of FLVCR1 transcripts and subsequent FLVCR1 insufficiency is an additional contributing factor to the erythropoietic defect observed in Diamond-Blackfan anemia. PMID: 18815190

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  • 相关疾病：
    Posterior column ataxia with retinitis pigmentosa (PCARP)
  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family
  • 组织特异性：
    Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.
  • 数据库链接：

    HGNC: 24682

    OMIM: 609033

    KEGG: hsa:28982

    STRING: 9606.ENSP00000355938

    UniGene: Hs.7055