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  4. Recombinant Human Endophilin-A3 (SH3GL3)

Recombinant Human Endophilin-A3 (SH3GL3)

  • 中文名称：
    人SH3GL3重组蛋白
  • 货号：
    CSB-YP860359HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SH3GL3重组蛋白
  • 货号：
    CSB-EP860359HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SH3GL3重组蛋白
  • 货号：
    CSB-EP860359HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SH3GL3重组蛋白
  • 货号：
    CSB-BP860359HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SH3GL3重组蛋白
  • 货号：
    CSB-MP860359HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CNSA3; EEN 2B L3; EEN B2; EEN-B2; EEN2BL3; EENB2; Endophilin 3; Endophilin A3; Endophilin-3; Endophilin-A3; H.sapiens mRNA for protein containing SH3 domain, SH3GL3; HsT19371; SH3 domain containing GRB2 like protein 3; SH3 domain GRB2 like 3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3; SH3D2C; SH3G3_HUMAN; SH3GL3; SH3P13
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-347
  • 氨基酸序列
    MSVAGLKKQF HKASQLFSEK ISGAEGTKLD DEFLDMERKI DVTNKVVAEI LSKTTEYLQP NPAYRAKLGM LNTVSKIRGQ VKTTGYPQTE GLLGDCMLKY GKELGEDSTF GNALIEVGES MKLMAEVKDS LDINVKQTFI DPLQLLQDKD LKEIGHHLKK LEGRRLDYDY KKKRVGKIPD EEVRQAVEKF EESKELAERS MFNFLENDVE QVSQLAVFIE AALDYHRQST EILQELQSKL QMRISAASSV PRREYKPRPV KRSSSELNGV STTSVVKTTG SNIPMDQPCC RGLYDFEPEN QGELGFKEGD IITLTNQIDE NWYEGMIHGE SGFFPINYVE VIVPLPQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
  • 基因功能参考文献：
    1. Our findings indicate that SH3GL3 plays an important role in myeloma cell migration/invasion, stemness and chemo-resistance. The SH3GL3-mediated myeloma cell migration/invasion is mediated by FAK/PI3K signaling pathway. PMID: 27683032
    2. Aberrant DNA methylation of SH3GL3 gene is associated with colorectal cancer. PMID: 22901147
    3. SH3GL3 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas. PMID: 21722156
    4. These data implicate ataxin-2 to play a role in endocytic receptor cycling.[Endophilin A3] PMID: 18602463
    5. importance of hapln1b and sh3gl3 in embryonic vascular development PMID: 19308258

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  • 亚细胞定位：
    Cytoplasm. Early endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Endophilin family
  • 组织特异性：
    Brain and testis.
  • 数据库链接：

    HGNC: 10832

    OMIM: 603362

    KEGG: hsa:6457

    STRING: 9606.ENSP00000391372

    UniGene: Hs.270055