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  4. Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19), partial

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19), partial

  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19(ADAM19),partial,Yeast
  • 货号：
    CSB-YP880929HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19(ADAM19),partial,Yeast
  • 货号：
    CSB-EP880929HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19(ADAM19),partial,Yeast
  • 货号：
    CSB-EP880929HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19(ADAM19),partial,Yeast
  • 货号：
    CSB-BP880929HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19(ADAM19),partial,Yeast
  • 货号：
    CSB-MP880929HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ADAM19
  • Uniprot No.：
  • 别名：
    ADAM19; MLTNB; FKSG34Disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; EC 3.4.24.-; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone.
  • 基因功能参考文献：
    1. 3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease. PMID: 27078193
    2. ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer. PMID: 26912236
    3. these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells PMID: 26823772
    4. miR-30c inhibited colon cancer cells via targeting ADAM19. PMID: 25799050
    5. four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease. PMID: 25114068
    6. ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function. PMID: 24951661
    7. MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 PMID: 25475731
    8. ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls. PMID: 23429442
    9. Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments. PMID: 21270819
    10. Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma. PMID: 21239057
    11. These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2. PMID: 20460109
    12. ADAM19 correlates with the progress and prognosis of endometrial carcinoma. PMID: 18458692
    13. ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation. PMID: 19727588
    14. activation by furin via one of two consecutive recognition sites PMID: 12006600
    15. investigation of proteolytic activity PMID: 12393862
    16. yeast two-hybrid screen performed in fetal brain cDNA library isolated four proteins that interact with the cytoplasmic tail of ADAM19 PMID: 12463424
    17. A new autolytic processing site at Lys543-Val544 was identified in soluble mutants of ADAM19 when these cysteine residues were individually mutated to serine residues. PMID: 15242783
    18. ChIP assays demonstrated high levels of acetylated histone H3 in the promoter region of the MADDAM gene in TSA-treated THP-1 cells/dendritic cells compared to macrophages, indicating an important role of histone acetylation in regulating the MADDAM gene. PMID: 15896713
    19. ADAM19 may have a modulatory role in the dysfunctional renal allograft state PMID: 16827870
    20. results suggest that ADAM19 has a constitutive alpha-secretase activity for amyloid precursor protein PMID: 17112471
    21. we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer. PMID: 18714391

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in many normal organ tissues and several cancer cell lines.
  • 数据库链接：

    HGNC: 197

    OMIM: 603640

    KEGG: hsa:8728

    STRING: 9606.ENSP00000257527

    UniGene: Hs.483944