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  4. Recombinant Human Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1)

Recombinant Human Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1)

  • 中文名称：
    人DNTTIP1重组蛋白
  • 货号：
    CSB-YP880940HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DNTTIP1重组蛋白
  • 货号：
    CSB-EP880940HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DNTTIP1重组蛋白
  • 货号：
    CSB-EP880940HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DNTTIP1重组蛋白
  • 货号：
    CSB-BP880940HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DNTTIP1重组蛋白
  • 货号：
    CSB-MP880940HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DNTTIP1
  • Uniprot No.：
  • 别名：
    C20orf167; Deoxynucleotidyltransferase terminal interacting protein 1; Deoxynucleotidyltransferase terminal-interacting protein 1; dJ447F3.4; DNTTIP1; TdIF 1; TdIF1; TDIF1_HUMAN; TdT binding protein; TdT interacting factor 1; TdT-interacting factor 1; Terminal deoxynucleotidyltransferase interacting factor 1; Terminal deoxynucleotidyltransferase-interacting factor 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-329
  • 氨基酸序列
    MGATGDAEQP RGPSGAERGG LELGDAGAAG QLVLTNPWNI MIKHRQVQRR GRRSQMTTSF TDPAISMDLL RAVLQPSINE EIQTVFNKYM KFFQKAALNV RDNVGEEVDA EQLIQEACRS CLEQAKLLFS DGEKVIPRLT HELPGIKRGR QAEEECAHRG SPLPKKRKGR PPGHILSSDR AAAGMVWKPK SCEPIRREGP KWDPARLNES TTFVLGSRAN KALGMGGTRG RIYIKHPHLF KYAADPQDKH WLAEQHHMRA TGGKMAYLLI EEDIRDLAAS DDYRGCLDLK LEELKSFVLP SWMVEKMRKY METLRTENEH RAVEAPPQT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
  • 基因功能参考文献：
    1. In luciferase assays, TdIF1 can up-regulate transcription activity of the promoters containing the TdIF1-binding sequences, and this effect is mainly through the palindrome 5'-TGCATG-3'. PMID: 25619743
    2. During cell division, DNTTIP1 is part of the mitotic deacetylase complex MIDAC, which also contains C14ORF43/MIDEAS and HDAC1/HDAC2. PMID: 21258344
    3. During cell division, DNTTIP1 forms a complex with C14ORF43/MIDEAS and HDAC1/HDAC2. PMID: 21258344
    4. The TdT binding, DNA binding and dimerization regions, and nuclear localization signal (NLS) in TdIF1, were identified. PMID: 17663723
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16160

    OMIM: 611388

    KEGG: hsa:116092

    STRING: 9606.ENSP00000361705

    UniGene: Hs.472852