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  4. Recombinant Human Coiled-coil domain-containing protein C6orf97 (C6orf97)

Recombinant Human Coiled-coil domain-containing protein C6orf97 (C6orf97)

  • 货号：
    CSB-YP815585HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP815585HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP815585HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP815585HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP815585HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CCDC170
  • Uniprot No.：
  • 别名：
    bA282P11.1; CC170_HUMAN; CCDC170; Chromosome 6 open reading frame 97; Coiled coil domain containing protein C6orf97; Coiled-coil domain-containing protein 170; FLJ23305; Hypothetical protein LOC80129; LOC80129
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-715
  • 氨基酸序列
    MSLDCTSHIA LGAASPAPEE TYDHLSEVPV TREQLNHYRN VAQNARSELA ATLVKFECAQ SELQDLRSKM LSKEVSCQEL KAEMESYKEN NARKSSLLTS LRDRVQELEE ESAALSTSKI RTEITAHAAI KENQELKKKV VELNEKLQKC SKENEENKKQ VSKNCRKHEE FLTQLRDCLD PDERNDKASD EDLILKLRDL RKENEFVKGQ IVILEETINV HEMEAKASRE TIMRLASEVN REQKKAASCT EEKEKLNQDL LSAVEAKEAL EREVKIFQER LLAGQQVWDA SKQEVSLLKK SSSELEKSLK ASQDAVTTSQ SQYFSFREKI AALLRGRLSM TGSTEDTILE KIREMDSREE SRDRMVSQLE AQISELVEQL GKESGFHQKA LQRAQKAENM LETLQGQLTH LEAELVSGGV LRDNLNFEKQ KYLKFLDQLS QKMKLDQMAA ELGFDMRLDV VLARTEQLVR LESNAVIENK TIAHNLQRKL KTQKERLESK ELHMSLLRQK IAQLEEEKQA RTALVVERDN AHLTIRNLQK KVERLQKELN TCRDLHTELK AKLADTNELK IKTLEQTKAI EDLNKSRDQL EKMKEKAEKK LMSVKSELDT TEHEAKENKE RARNMIEVVT SEMKTLKKSL EEAEKREKQL ADFREVVSQM LGLNVTSLAL PDYEIIKCLE RLVHSHQHHF VTCACLKDVT TGQERHPQGH LQLLH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in Golgi-associated microtubules organization and stabilization.
  • 基因功能参考文献：
    1. Findings demonstrate that CCDC170 plays an essential role in Golgi-associated microtubules organization and stabilization, and implicate a mechanism for how perturbations in the CCDC170 gene may contribute to the hallmark changes in cell polarity and motility seen in breast cancer. PMID: 28687497
    2. Data suggest that rs2046210 SNPs located in the region of C6ORF97 (CCDC170)-estrogen receptor alpha (ESR1) might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients. PMID: 25370037
    3. Our findings suggest that ESR1 and C6orf97 gene polymorphism is associated with fracture and vertebral fracture risk in Chinese postmenopausal women. PMID: 24481879
    4. ESR1-CCDC170 rearrangements are found in an aggressive subset of estrogen receptor-positive breast cancers PMID: 25099679
    5. Variation in rs3757318 of C6orf97 is associated with breast cancer risk. PMID: 25338983
    6. SNPs associated with breast cancer differ for Asian, European, and African ancestry groups PMID: 20661439

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  • 亚细胞定位：
    Golgi apparatus.
  • 数据库链接：

    HGNC: 21177

    KEGG: hsa:80129

    STRING: 9606.ENSP00000239374

    UniGene: Hs.660044