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  4. Recombinant Danio rerio Rhombotin-2 (lmo2)

Recombinant Danio rerio Rhombotin-2 (lmo2)

  • 中文名称：
    斑马鱼lmo2重组蛋白
  • 货号：
    CSB-YP886095DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼lmo2重组蛋白
  • 货号：
    CSB-EP886095DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼lmo2重组蛋白
  • 货号：
    CSB-EP886095DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼lmo2重组蛋白
  • 货号：
    CSB-BP886095DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼lmo2重组蛋白
  • 货号：
    CSB-MP886095DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    lmo2
  • Uniprot No.：
  • 别名：
    lmo2; si:dkey-10o6.5; Rhombotin-2; LIM domain only protein 2; LMO-2; zlmo2
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-159
  • 氨基酸序列
    MASTIERKTL EANEEPVDEV LQMPPSLLTC GGCQQSIGDR FFLKAIEQYW HEDCLSCDLC GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCEKR IRAFEMTMRV RDKVYHLECF KCAACQKHFC VGDRYLLINS DIVCEQDIFE WTKLNGSIV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells.
  • 基因功能参考文献：
    1. The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro. Furthermore, LMO2 is required for angiogenesis and tissue healing in vivo. Thus, LMO2 is a critical determinant of vascular and tissue regeneration. PMID: 27792641
    2. a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure PMID: 22819672
    3. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells PMID: 14602685
    4. Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated. PMID: 15893977
    5. Scl/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other PMID: 17090656

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    During embryogenesis, expressed in hematopoietic and endothelial precursors, including the two stripes of posterior and anterior lateral plate mesoderm at the 1-somite stage that give rise to the primitive blood.
  • 数据库链接：

    KEGG: dre:30332

    STRING: 7955.ENSDARP00000115969

    UniGene: Dr.79808