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  4. Recombinant Danio rerio Pancreas transcription factor 1 subunit alpha (ptf1a)

Recombinant Danio rerio Pancreas transcription factor 1 subunit alpha (ptf1a)

  • 中文名称：
    斑马鱼ptf1a重组蛋白
  • 货号：
    CSB-YP770375DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼ptf1a重组蛋白
  • 货号：
    CSB-EP770375DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼ptf1a重组蛋白
  • 货号：
    CSB-EP770375DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼ptf1a重组蛋白
  • 货号：
    CSB-BP770375DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼ptf1a重组蛋白
  • 货号：
    CSB-MP770375DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ptf1a
  • Uniprot No.：
  • 别名：
    ptf1a; si:zc142h2.2; zgc:112216; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; bHLH transcription factor p48
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-265
  • 氨基酸序列
    MDTVLDPFTG LDSFSSSYFD DDDFFTDHSS RDHLDTDDFL DEDVDFLTNQ IQEYYKDSRI SQDGDYCDVG NFSFSSSSST FSYGCADSTS ELSPHRDGGL LKRRRRMRSE VEMQQLRQAA NVRERRRMQS INDAFEGLRS HIPTLPYEKR LSKVDTLRLA IGYINFLAEL VQSDMPIRNP HSDALNQPKK VIICHRGTRS PSPNDPDYGL PPLAGHSLSW TDEKQLKDQN IIRTAKVWTP EDPRKLHLKS SINNIENEPP FNFIS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
  • 基因功能参考文献：
    1. Results highlight the possibility that Ptf1a may act as an important transcription factor for enteric neuron development. PMID: 26865080
    2. In ptf1a haploinsufficiency, more ptf1a-lineage-labeled cells are traced into the pancreatic Notch-responsive cell and endocrine compartments. More reduction of ptf1a gene dosage converts pancreatic progenitor cells to non-pancreatic cell fates. PMID: 25773748
    3. Autoregulation of ptf1a is absolutely required for exocrine pancreas formation. PMID: 23876428
    4. Postembryonic antagonism of Ptf1a, a master regulator of pancreatic development and acinar cell fate specification, induced expression of endocrine genes including insulin in the exocrine compartment. Induced insulin+ cells are derived from acinar cells. PMID: 21497092
    5. The timing of Ptf1a expression suggests that it is involved in the very early stages or steps in the differentiation of amacrine cells, which can be seen to rapidly diversify into a large number of subtypes. PMID: 19732413
    6. mapping, analysis of embryonic expression and role in pancreas development PMID: 15031114
    7. Ptf1 function is inhibited by notch PMID: 15280211
    8. We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate. PMID: 18519637
    9. Exocrine differentiation and proliferation factor (exdpf) is a direct target gene of pancreas-specific transcription factor 1a (Ptf1a). PMID: 19067490

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dre:368662

    STRING: 7955.ENSDARP00000011265

    UniGene: Dr.86563