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VWA2 Antibody

  • 中文名称：
    VWA2兔多克隆抗体
  • 货号：
    CSB-PA025951GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q5GFL6
  • 基因名：
    VWA2
  • 别名：
    A domain-containing protein similar to matrilin and collagen antibody; AMACO antibody; CCSP-2 antibody; Colon cancer secreted protein 2 antibody; von Willebrand factor A domain-containing protein 2 antibody; VWA2 antibody; VWA2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human VWA2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. We have revealed a novel Ca((2)+)-binding site at the A2 domain of VWF and demonstrated a relationship between Ca((2)+) and force in the regulation of VWF and primary hemostasis PMID: 21385852
    2. AMACO is a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney PMID: 14506275
    3. CCSP-2 is a novel candidate for development as a diagnostic serum marker of early stage colon cancer PMID: 15580307
    4. Single nucleotide polymorphisms in the AMACO gene are associated with dominant protection against Type 1A diabetes in an Arab family. PMID: 15699509
    5. O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO PMID: 18434322
    6. By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668). PMID: 18492952
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expression is generally absent in normal colon and other normal body tissues, but it is induced an average of 78-fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines.
  • 数据库链接：

    HGNC: 24709

    KEGG: hsa:340706

    STRING: 9606.ENSP00000298715

    UniGene: Hs.197741