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UBE2T Antibody

  • 中文名称：
    UBE2T兔多克隆抗体
  • 货号：
    CSB-PA004361
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using UBE2T Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NPD8
  • 基因名：
    UBE2T
  • 别名：
    Cell proliferation inducing gene 50 protein antibody; Cell proliferation-inducing gene 50 protein antibody; HSPC150 antibody; HSPC150 protein similar to ubiquitin conjugating enzyme antibody; PIG50 antibody; Ube2t antibody; UBE2T_HUMAN antibody; Ubiquitin carrier protein T antibody; Ubiquitin conjugating enzyme antibody; ubiquitin conjugating enzyme E2 T antibody; Ubiquitin conjugating enzyme E2T antibody; Ubiquitin protein ligase T antibody; Ubiquitin-conjugating enzyme E2 T antibody; Ubiquitin-protein ligase T antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human UBE2T.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
  • 基因功能参考文献：
    1. Results show that UBE2T expression was increased in gastric tumors. Its suppression altered the expression of epithelial-mesenchymal transition factors and inhibited growth and colony formation, increased G2/M phase cell cycle arrest, and promoted apoptosis in gastric cancer cells. These findings provide evidence that UBE2T plays a critical role in gastric cancer. PMID: 28427240
    2. High UBE2T expression is associated with nasopharyngeal carcinoma. PMID: 26943030
    3. Collectively, our findings suggest UBE2T serves as a promising prognostic factor for HCC and functions as an oncogene. The newly identified miR-543/UBE2T/p53 axis may represent a new potential therapeutic target for HCC intervention. PMID: 28935368
    4. report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro PMID: 28437106
    5. Results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion. PMID: 27712593
    6. UBE2T plays an important role in the tumorigenesis of gastric cancer and could act as a potential independent prognostic factor for cancer therapy. PMID: 27020591
    7. Identify critical roles of UBE2T in prostate cancer development and progression. PMID: 26308072
    8. we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susceptibility gene. PMID: 26085575
    9. UBE2T is the primary E2 of the FA pathway required for FANCD2 and FANCI activation. PMID: 26119737
    10. Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia PMID: 26046368
    11. hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway PMID: 21722982
    12. UBE2T is the ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway. PMID: 16916645
    13. UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype. PMID: 18667844
    14. This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination. PMID: 19111657
    15. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair. PMID: 19589784
    16. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex. PMID: 19887602

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  • 相关疾病：
    Fanconi anemia complementation group T (FANCT)
  • 亚细胞定位：
    Nucleus. Note=Accumulates to chromatin.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 数据库链接：

    HGNC: 25009

    OMIM: 610538

    KEGG: hsa:29089

    STRING: 9606.ENSP00000356243

    UniGene: Hs.5199