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U2AF1L4 Antibody

  • 中文名称：
    U2AF1L4兔多克隆抗体
  • 货号：
    CSB-PA837850ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA837850ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA837850ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) U2AF1L4 Polyclonal antibody
  • Uniprot No.：
    Q8WU68
  • 基因名：
    U2AF1L4
  • 别名：
    FLJ35525 antibody; MGC33901 antibody; Splicing factor U2AF 26 kDa subunit antibody; U2 auxiliary factor 26 antibody; U2 small nuclear RNA auxiliary factor 1 like 3 antibody; U2 small nuclear RNA auxiliary factor 1 like 4 antibody; U2 small nuclear RNA auxiliary factor 1 like protein 3 antibody; U2 small nuclear RNA auxiliary factor 1 like protein 4 antibody; U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody; U2 small nuclear RNA auxiliary factor 1-like protein 4 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1 like 3 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 antibody; U2AF1 like protein 3 antibody; U2AF1 RS3 antibody; U2AF1-like protein 3 antibody; U2AF1L3V1 antibody; U2AF1L4 antibody; U2AF1RS3 antibody; U2af26 antibody; U2AF4_HUMAN antibody; U2RNU2 small nuclear RNA auxiliary factor 1 like 3 antibody; U2RNU2 small nuclear RNA auxiliary factor 1 like protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Splicing factor U2AF 26 kDa subunit protein (1-202AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA.
  • 基因功能参考文献：
    1. U2AF1L4 gene expression is regulated by cytokines in activated T cells. PMID: 27143377
    2. One of the conservative regions is responsible for the enhancer activity and is able to interact with proteins of HeLa cell nuclear extract. PMID: 22022969
    3. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26 PMID: 18460468
  • 亚细胞定位：
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    Splicing factor SR family
  • 组织特异性：
    Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 23020

    OMIM: 601080

    KEGG: hsa:199746

    UniGene: Hs.351558