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RPLP0 Antibody

  • 中文名称：
    RPLP0兔多克隆抗体
  • 货号：
    CSB-PA153990
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA153990(RPLP0 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA153990(RPLP0 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, 293T cells, A431 cells, Jurkat cells, Primary antibody: CSB-PA153990(RPLP0 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    P05388
  • 基因名：
    RPLP0
  • 别名：
    36B4 antibody; 60S acidic ribosomal protein P0 antibody; 60S ribosomal protein L10E antibody; Acidic ribosomal phosphoprotein P0 antibody; Arbp antibody; L10E antibody; LP0 antibody; MGC107165 antibody; MGC107166 antibody; MGC111226 antibody; MGC88175 antibody; OTTMUSP00000015585 antibody; P0 antibody; PRLP0 antibody; Ribosomal phosphoprotein; acidic; P0 antibody; Ribosomal protein P0 antibody; Ribosomal protein; large; P0 antibody; RLA0_HUMAN antibody; rplP0 antibody; RPP0 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human RPLP0
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
  • 基因功能参考文献：
    1. The presence of uL10 on the ribosomes is affected in stressed cells, thus it might be considered as a regulatory element responding to environmental fluctuations. PMID: 28986221
    2. absence of RPLP0, RPLP1, or RPLP2 resulted in reactive oxygen species (ROS) accumulation and MAPK1/ERK2 signaling pathway activation. PMID: 26176264
    3. This study shows a spontaneous humoral immune response to ribosomal P0 protein in colorectal cancer patients. PMID: 25889931
    4. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells PMID: 25433997
    5. the immune response mediated by serum anti-RPLP0 and anti-galectin 3 antibodies plays a key role in the pathogenesis of SLE skin lesions. These findings provide new insights into the mechanism of SLE-related organ disorders. PMID: 25307291
    6. Evaluated autoantibodies against native ribosomal P complex and recombinant ribosomal P proteins (anti-Rib-P0, anti-Rib-P1, anti-Rib-P2) for prevalence, diagnostic relevance&clinical associations in a Chinese cohort with systemic lupus erythematosus. PMID: 23400861
    7. P proteins are up-regulated in a considerable number of patients with the most common types of cancer. PMID: 21040949
    8. The P0 protein was found in the cytoplasm, as well as in the nucleus; however, the nucleoli were excluded. This protein was scattered around the nuclei, and the distribution might reflect association with the so-called nuclear bodies PMID: 12479870
    9. Recombinant fusion protein GST.P0 expressed in insect cells, but not the protein obtained in Escherichia coli, had the ability to form a complex with P1 and P2 proteins. PMID: 15336536
    10. P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 17621266

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Universal ribosomal protein uL10 family
  • 数据库链接：

    HGNC: 10371

    OMIM: 180510

    KEGG: hsa:6175

    STRING: 9606.ENSP00000339027

    UniGene: Hs.546285