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RIC8B Antibody

  • 中文名称：
    RIC8B兔多克隆抗体
  • 货号：
    CSB-PA019709GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NVN3
  • 基因名：
    RIC8B
  • 别名：
    Brain synembrin antibody; brain synembryn antibody; hSyn antibody; Protein Ric-8B antibody; resistance to inhibitors of cholinesterase 8 homolog B (C. elegans) antibody; RIC8, C. elegans, homolog of, B antibody; Ric8b antibody; RIC8B_HUMAN antibody; Synembryn, C. elegans, homolog of, B antibody; Synembryn-B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RIC8B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.
  • 基因功能参考文献：
    1. these data show the existence of functional CREB and C/EBP binding sites in the human RIC8B gene promoter, a particular distribution of these sites and demonstrate a relevant role of CREB in stimulating transcriptional activity of this gene. PMID: 26729411
    2. overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF PMID: 26966186
    3. Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling PMID: 20133939
    4. We identified a protein member of the synembryn family as one of the interacting proteins in human brain. Gqalpha also interacts with synembryn. Synembryn translocates to the plasma membrane in response to carbachol and isoproterenol. PMID: 12652642
  • 亚细胞定位：
    Cytoplasm, cell cortex. Note=Localizes to the cell cortex.
  • 蛋白家族：
    Synembryn family
  • 数据库链接：

    HGNC: 25555

    OMIM: 609147

    KEGG: hsa:55188

    STRING: 9606.ENSP00000376583

    UniGene: Hs.131306