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Phospho-FBXL3 (Ser320) Antibody

  • 中文名称：
    磷酸化-FBXL3 (Ser320)兔多克隆抗体
  • 货号：
    CSB-PA976364
  • 规格：
    ￥2454
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXL3 Polyclonal antibody
  • Uniprot No.：
    Q9UKT7
  • 基因名：
    FBXL3
  • 宿主：
    Rabbit
  • 反应种属：
    Humann,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 320 (S-V-S(p)-K-D) derived from Human FBXL3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
  • 基因功能参考文献：
    1. data indicate an oncogenic role of miR-181d in CRC by promoting glycolysis, and miR-181d/CRY2/FBXL3/c-myc feedback loop might be a therapeutic target for patients with CRC. PMID: 28749470
    2. These results demonstrate that CRY2 stability controlled by FBXL3 plays a key role in the regulation of human sleep wake behavior. PMID: 27529127
    3. CRY2 and FBXL3 cooperatively degrade c-MYC preventing the development of cancer. PMID: 27840026
    4. Data show that CRISPR/Cas9 genome editing generated F-box and leucine-rich repeat protein 3 (Fbxl3) knockout in circadian clock model U2OS cells. PMID: 26243628
    5. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. PMID: 24085301
    6. Mutation in the Fbxl3 protein reveals distinct roles for CRY1 and CRY2 in the circadian molecular clockwork. PMID: 23616524
    7. crystal structures of mammalian CRY2 in its apo, FAD-bound and FBXL3-SKP1-complexed forms PMID: 23503662
    8. study demonstrates that the SCF(Fbxl3)ubiquitin ligase controls the oscillations of the circadian clock by mediating the degradation of Cry1 and Cry2 proteins PMID: 17463251

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Predominantly nuclear.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 13599

    OMIM: 605653

    KEGG: hsa:26224

    STRING: 9606.ENSP00000347834

    UniGene: Hs.508284