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Pcsk2 Antibody

  • 中文名称：
    Pcsk2兔多克隆抗体
  • 货号：
    CSB-PA017642LA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate
      All lanes: Pcsk1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 71 kDa
      Observed band size: 71 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Pcsk2 Polyclonal antibody
  • Uniprot No.：
    P28841
  • 基因名：
    Pcsk2
  • 别名：
    Pcsk2 antibody; Nec-2 antibody; Nec2 antibody; Rpc2 antibody; Neuroendocrine convertase 2 antibody; NEC 2 antibody; EC 3.4.21.94 antibody; KEX2-like endoprotease 2 antibody; Prohormone convertase 2 antibody; Proprotein convertase 2 antibody; PC2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat, Human
  • 免疫原：
    Recombinant Rat Neuroendocrine convertase 2 protein (109-637AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Pcsk2 Antibody (CSB-PA017642LA01RA)，的标记方式是Non-conjugated。对于Pcsk2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017642LB01RA Pcsk2 Antibody, HRP conjugated ELISA
    FITC CSB-PA017642LC01RA Pcsk2 Antibody, FITC conjugated
    Biotin CSB-PA017642LD01RA Pcsk2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
  • 基因功能参考文献：
    1. The nutrient sensor sirtuin 1 regulates the production of CRH post-translationally by affecting PC2 post-translationally by affecting PC2. PMID: 26755731
    2. The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin. PMID: 19628676
    3. The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain PMID: 14608596
    4. Leptin regulates hypothalamic Pcsk2 expression and requires prohormone processing into mature peptides. PMID: 15286802
    5. study demonstrates abundant expression of PC2 mRNA in rat brain and shows that thyroid status regulated PC2 expression in the hypothalamus and cortex [PC2] PMID: 15585599
    6. Expression levels of POMC processing enzymes prohormone convertases 1 and 2 (PC1/PC2) were not significantly affected by high dietary salt intake in either WKY or SP-SHR tissues. PMID: 17531155
    7. our data anticipate the possibility that carboxypeptidase-E, prohormone convertase 1, and prohormone convertase 2 might be potential target for the maturation of somatostatin PMID: 17543468
    8. PC1/PC3 and PC2 (specific to neural and endocrine cells) are absent in undifferentiated bone marrow stromal stem cells, their expression is initiated upon the induction of differentiation PMID: 17556096
    9. brain ischemia attenuates PC2 and PC2-mediated neuropeptide processing. PMID: 19142196
    10. PC2, CPE and preproNPY protein expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; differentiated cells or tissues had higher or highest PC2 activity PMID: 19428990

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle. Secreted.
  • 蛋白家族：
    Peptidase S8 family, Furin subfamily
  • 数据库链接：

    KEGG: rno:25121

    STRING: 10116.ENSRNOP00000007249

    UniGene: Rn.89052