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PKNOX1 Antibody

  • 中文名称：
    PKNOX1兔多克隆抗体
  • 货号：
    CSB-PA018077GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P55347
  • 基因名：
    PKNOX1
  • 别名：
    Homeobox protein PKNOX1 antibody; Homeobox protein PREP-1 antibody; Human homeobox containing protein antibody; Pbx regulating protein 1 antibody; PBX/knotted 1 homeobox 1 antibody; PBX/knotted homeobox 1 antibody; Pknox1 antibody; PKNX1_HUMAN antibody; pkonx1c antibody; PREP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PKNOX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates transcription in the presence of PBX1A and HOXA1.
  • 基因功能参考文献：
    1. PREP1 modulates the cellular sensitivity to TGF-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation. PMID: 25157139
    2. High levels of MEIS1 and PREP1, and low levels of PBX4 expression were founded in samples of patients with ALL. PMID: 22185299
    3. Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia PMID: 22347417
    4. The tumor suppressor role of Prep1 is associated with the maintenance of genomic stability. PMID: 21715654
    5. analysis of the regulatory region of the zebrafish Prep1.1 gene and the promoter of human PREP1 PMID: 21203543
    6. Immunohistochemistry on tissue micrroarrays (TMA) generated from three distinct human cohorts comprising a total of some 1000 human tumors revealed that 70% of the tumors express no or extremely low levels of Prep1, unlike normal tissues. PMID: 20106730
    7. PKNOX1 gene-dosage imbalance is associated with overexpression of FABP7 in Down syndrome fetal brains. PMID: 12771203
    8. PREP-1 has a role in F9 teratocarcinoma cells: it causes an increase of PBX-2 by preventing its degradation PMID: 12871956

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/MEIS homeobox family
  • 组织特异性：
    Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow.
  • 数据库链接：

    HGNC: 9022

    OMIM: 602100

    KEGG: hsa:5316

    STRING: 9606.ENSP00000291547

    UniGene: Hs.431043