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  4. PDLIM7 Antibody

PDLIM7 Antibody

  • 中文名称：
    PDLIM7兔多克隆抗体
  • 货号：
    CSB-PA017737GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NR12
  • 基因名：
    PDLIM7
  • 别名：
    1110003B01Rik antibody; Enigma antibody; LIM domain protein antibody; LIM domain protein enigma antibody; LIM mineralization protein 1 antibody; Lim mineralization protein 3 antibody; LIM mineralization protein antibody; LMP 1 antibody; LMP antibody; LMP1 antibody; LMP3 antibody; PDLI7_HUMAN antibody; PDLIM 7 antibody; Pdlim7 antibody; PDZ and LIM doamin protein 7 antibody; PDZ and LIM domain 7 antibody; PDZ and LIM domain protein 7 antibody; Protein enigma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PDLIM7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway.
  • 基因功能参考文献：
    1. In enigma siRNA-transfected cells, cell viability, and the protein levels of AKT and survivin decreased. PMID: 29848705
    2. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
    3. Molecular basis of the overactive osteogenic process may at least in part involve a deregulation of the LMP-related pathway in calvarial cells. PMID: 22982077
    4. The results showed that LMP-1 inhibited cell apoptosis and induced survivin expression in nasal natural killer/T-cell lymphoma PMID: 25760809
    5. The results suggest local transduction with LMP-1 gene promotes osteogenesis and mineralization in distraction osteogenesis. PMID: 25641592
    6. LMP-1 mRNA level was regulated in a dose-dependent manner after transfection PMID: 25336289
    7. These results are consistent with a model in which binding of OspE to PDLIM7 during infection regulates the activity of PKC isoforms that bind to the PDLIM7 LIM domain. PMID: 25124035
    8. LMP1 expression suppressed the expression of Runx2 and BMP-2 in OS cells. PMID: 24762763
    9. High Enigma expression is associated with breast neoplasms. PMID: 24466333
    10. A direct interaction of Jab1 with LMP-1, is reported. PMID: 24078030
    11. Gene transfer of LMP3 upregulated Alkaline Phosphatase, Bone Sialoprotein and BMP2 gene expression and increased in vitro matrix mineralization in human PDL cell line. PMID: 22241179
    12. LMP3 induced the successful osteogenic differentiation of AFSC by inducing the expression of osteogenic markers and osteospecific transcription factors. PMID: 23097599
    13. findings indicate the existence of a new cell cycle-associated signaling pathway in which LMP1 regulates ERK-mediated Op18/stathmin signaling PMID: 22417000
    14. results suggested that LMP3 could affect the fine balance between cell proliferation/differentiation of mesenchymal cells mostly by modulating the TGF-beta1 signaling pathway PMID: 21061915
    15. SRF and Enigma coexpressed with MDM2 but not p53 in several liver and stomach tumors. PMID: 21060154
    16. LMP1 is a downstream gene of TGF-beta1, involved in periodontal ligament cell proliferation. PMID: 20348040
    17. isolated the complementary DNA (cDNA) for the human homologue of LMP-1 from an adult human heart cDNA library and showed that when overexpressed it is osteoinductive PMID: 11874232
    18. LIM-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads PMID: 16611643
    19. Enigma is involved in insulin-induced Glut 4 translocation by regulating cortical actin remodeling. PMID: 16803868
    20. s hypothesize that the HIV-1 TAT interacting protein can fuse with PDLIM7 and that the fusion proteins could be easily transduced through biological membranes and have biological activity. PMID: 17126496
    21. When transferred into mouse muscle fibers, a truncated form of LMP-1 induces pluripotent myoblastic C2C12 cells to differentiate into osteoblastic lineage. PMID: 17805464
    22. LMP-1 was expressed primarily in predentin, odontoblasts and blood vessel endothelial cells of healthy teeth. LMP-1 expression was found in unmineralized reparative dentin, odontoblast-like cells and pulp fibroblasts in teeth with caries and pulpitis. PMID: 18215669
    23. These studies provide evidence that overexpression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. PMID: 18395833
    24. LMP1 mediates serine 256 phosphorylation and nuclear entry of Annexin A2 via PLC-PKCalpha/PKCbeta pathway. PMID: 18412141
    25. Immunofluorescence stained cell numbers are increased after 20 MOI AdLMP1-GFP infection concordant with upregulation of mRNA expression. PMID: 18618069
    26. absence of any hexosamines (N-acetyl glucosamine or N-acetyl galactosamine) in chemical composition analysis of LMP-1 protein revealed that there is little or no post-translational glycosylation of the LMP-1 polypeptide in lung carcinoma cells PMID: 18989571
    27. PAR-2 is a possible mediator cooperating with LMP-1 and MMP9 to influence the progression of nasopharyngeal carcinoma by inducing angiogenesis and promoting lymph node metastasis. PMID: 19269113

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver.
  • 数据库链接：

    HGNC: 22958

    OMIM: 605903

    KEGG: hsa:9260

    STRING: 9606.ENSP00000348099

    UniGene: Hs.533040