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PDCL3 Antibody

  • 中文名称：
    PDCL3兔多克隆抗体
  • 货号：
    CSB-PA872479LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A2780 whole cell lysate, 293 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
      All lanes: PDCL3 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 37 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA872479LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDCL3 Polyclonal antibody
  • Uniprot No.：
    Q9H2J4
  • 基因名：
    PDCL3
  • 别名：
    HTPHLP antibody; IAP associated factor VIAF1 antibody; MGC3062 antibody; PDCL 3 antibody; Pdcl3 antibody; PDCL3_HUMAN antibody; PHLP2A antibody; PHLP3 antibody; Phosducin like 3 antibody; Phosducin like protein 3 antibody; Phosducin-like protein 3 antibody; PhPL3 antibody; VIAF 1 antibody; VIAF antibody; VIAF-1 antibody; VIAF1 antibody; Viral IAP associated factor 1 antibody; Viral IAP-associated factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phosducin-like protein 3 protein (1-239AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDCL3 Antibody (CSB-PA872479LA01HU)，的标记方式是Non-conjugated。对于PDCL3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872479LB01HU PDCL3 Antibody, HRP conjugated ELISA
    FITC CSB-PA872479LC01HU PDCL3 Antibody, FITC conjugated
    Biotin CSB-PA872479LD01HU PDCL3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.
  • 基因功能参考文献：
    1. results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins. PMID: 27496612
    2. The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2. PMID: 26059764
    3. data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function. PMID: 23792958
    4. Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. PMID: 17429077
    5. This publication pertains to mouse. PMID: 12424248

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • 蛋白家族：
    Phosducin family
  • 组织特异性：
    Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
  • 数据库链接：

    HGNC: 28860

    OMIM: 611678

    KEGG: hsa:79031

    STRING: 9606.ENSP00000264254

    UniGene: Hs.469459