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PCSK4 Antibody

  • 中文名称：
    PCSK4兔多克隆抗体
  • 货号：
    CSB-PA017643GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6UW60
  • 基因名：
    PCSK4
  • 别名：
    PCSK4; PC4; UNQ2757/PRO6496; Proprotein convertase subtilisin/kexin type 4; Proprotein convertase 4; PC4
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PCSK4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2. May also participate in folliculogenesis in the ovaries.
  • 基因功能参考文献：
    1. Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells where it interacts with BiP. PMID: 21080038
    2. abnormal processing of IGF-II by PC4 may represent a previously uncharacterized mechanism involved in the pathophysiology of fetoplacental growth restriction PMID: 16040806
  • 亚细胞定位：
    Membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane.
  • 蛋白家族：
    Peptidase S8 family, Furin subfamily
  • 组织特异性：
    Placenta.
  • 数据库链接：

    HGNC: 8746

    OMIM: 600487

    KEGG: hsa:54760

    STRING: 9606.ENSP00000300954

    UniGene: Hs.46884