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N4BP1 Antibody

  • 中文名称：
    N4BP1兔多克隆抗体
  • 货号：
    CSB-PA003360
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using N4BP1 Polyclonal Antibody
    • Western Blot analysis of K562 cells using N4BP1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75113
  • 基因名：
    N4BP1
  • 别名：
    FLJ31821 antibody; KIAA0615 antibody; MGC176730 antibody; N4BP1 antibody; N4BP1_HUMAN antibody; NEDD4 binding protein 1 antibody; NEDD4-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human N4BP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines. Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates.
  • 基因功能参考文献：
    1. The p34 interacts with the WW1 domain of NEDD4-1, an interaction that enhances NEDD4-1 stability. PMID: 24141722
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body.
  • 蛋白家族：
    N4BP1 family
  • 组织特异性：
    Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
  • 数据库链接：

    HGNC: 29850

    KEGG: hsa:9683

    STRING: 9606.ENSP00000262384

    UniGene: Hs.511839