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MAGEF1 Antibody

  • 中文名称：
    MAGEF1兔多克隆抗体
  • 货号：
    CSB-PA272625
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA272625(MAGEF1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cells, human fetal liver tissue, Primary antibody: CSB-PA272625(MAGEF1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9HAY2
  • 基因名：
    MAGEF1
  • 别名：
    MAGE F1 antigen antibody; MAGE-F1 antigen antibody; MAGEF 1 antibody; MAGEF1 antibody; MAGF1_HUMAN antibody; Melanoma antigen family F; 1 antibody; Melanoma associated antigen F1 antibody; Melanoma-associated antigen F1 antibody; MGC19617 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MAGEF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair.
  • 基因功能参考文献：
    1. MAGE-F1 specifies the cytosolic iron-sulfur assembly pathway protein MMS19 for ubiquitination and degradation. PMID: 29225034
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 29639

    OMIM: 609267

    KEGG: hsa:64110

    STRING: 9606.ENSP00000315064

    UniGene: Hs.306123