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LRTOMT Antibody

  • 中文名称：
    LRTOMT兔多克隆抗体
  • 货号：
    CSB-PA02667A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA02667A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LRTOMT Polyclonal antibody
  • Uniprot No.：
    Q8WZ04
  • 基因名：
    LRTOMT
  • 别名：
    TOMT; COMT2; LRTOMT; PP7517; Transmembrane O-methyltransferase; Catechol O-methyltransferase 2; Protein LRTOMT2
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane O-methyltransferase protein (31-264AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LRTOMT Antibody (CSB-PA02667A0Rb)，的标记方式是Non-conjugated。对于LRTOMT Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA02667B0Rb LRTOMT Antibody, HRP conjugated ELISA
    FITC CSB-PA02667C0Rb LRTOMT Antibody, FITC conjugated
    Biotin CSB-PA02667D0Rb LRTOMT Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity.
  • 基因功能参考文献：
    1. Results indicate that mutations in the LRT)MT gene lead to alterations in the LRTOMT2 protein and might be involved in progressive sensorineural hearing loss. PMID: 25788562
    2. LRTOMT gene is the second cause of congenital hearing impairment in Moroccan patients. PMID: 23053991
    3. A 1 bp deletion in the dual reading frame deafness gene LRTOMT causes a frameshift from the first into the second reading frame. PMID: 21739586
    4. A genome wide linkage analysis of nonsyndromic deafness segregating in a consanguineous Pakistani family (PKDF537) was used to identify DFNB63, a new locus for congenital profound sensorineural hearing loss. PMID: 17066295
    5. Haplotype analysis defined a 5.55 Mb critical region between microsatellite markers D11S4136 and D11S4081. PMID: 17166180
    6. The locus associated with ARNSHI PMID: 17211611
    7. nonsense mutation in the human ortholog of the murine Comt2 gene that causes nonsyndromic deafness PMID: 18794526
    8. Mutations of LRTOMT are associated with profound nonsyndromic hearing loss at the DFNB63 locus on human chromosome 11q13.3-q13.4. PMID: 18953341

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  • 相关疾病：
    Deafness, autosomal recessive, 63 (DFNB63)
  • 亚细胞定位：
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Cytoplasm. Endoplasmic reticulum.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family
  • 数据库链接：

    HGNC: 25033

    OMIM: 611451

    KEGG: hsa:220074

    STRING: 9606.ENSP00000305742

    UniGene: Hs.317243