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  4. LIMA1 Antibody

LIMA1 Antibody

  • 中文名称：
    LIMA1兔多克隆抗体
  • 货号：
    CSB-PA012947GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHB6
  • 基因名：
    LIMA1
  • 别名：
    1110021C24Rik antibody; Epithelial protein lost in neoplasm antibody; Epithelial protein lost in neoplasm beta antibody; EPLIN antibody; FLJ38853 antibody; LIM domain and actin binding 1 antibody; LIM domain and actin binding protein 1 antibody; LIM domain and actin-binding protein 1 antibody; LIMA1 antibody; LIMA1_HUMAN antibody; MGC131726 antibody; SREBP3 antibody; Sterol regulatory element binding protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LIMA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake.
  • 基因功能参考文献：
    1. this study identifies LIMA1 as a key protein regulating intestinal cholesterol absorption. PMID: 29880681
    2. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. s therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
    3. Data provide evidence that downregulation of EPLIN-alpha may be associated with poor prognosis for patients with epithelial ovarian cancer (EOC), and that this molecule appears to play a tumour suppressor role by inhibition of EOC growth and migration. PMID: 27035883
    4. EPLIN is functionally linked to molecules like actin and paxillin and has been implicated in a number of potential pathways to enhance metastatic potential PMID: 26350886
    5. a major activity of DNp73 is to establish initiation of the invasion-metastasis cascade via EPLIN-dependent IGF1R regulation PMID: 24135282
    6. EGF promotes epithelial-mesenchymal transition and induces degradation of EPLIN, a putative suppressor of prostate cancer metastasis. PMID: 23188829
    7. Together with the findings that EPLIN-alpha inhibits cellular growth and invasion, we conclude that EPLIN-alpha is a tumour suppressor of oesophageal cancer PMID: 22493360
    8. EPLIN clutch is necessary for stabilization of capillary structures in an angiogenesis model. PMID: 22194609
    9. EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. PMID: 21625216
    10. EPLINalpha over-expression can regulate HECV cell motility, matrix adhesion and tubule formation in vitro and slow in vivo tumour formation, suggesting an anti-angiogenic role for EPLINalpha. PMID: 20848180
    11. EPLIN functions to link the cadherin-catenin complex to F-actin and simultaneously stabilizes this population of actin fibers, resulting in the establishment of the adhesion PMID: 18093941
    12. expression of EPLIN-alpha in breast cancer is down-regulated in breast cancer cells . PMID: 18796137
    13. EPLIN protein may function during cytokinesis to maintain local accumulation of key cytokinesis proteins at the furrow. PMID: 19221476

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  • 亚细胞定位：
    Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell membrane.
  • 组织特异性：
    Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform
  • 数据库链接：

    HGNC: 24636

    OMIM: 608364

    KEGG: hsa:51474

    STRING: 9606.ENSP00000378400

    UniGene: Hs.525419