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LHX1 Antibody

  • 中文名称：
    LHX1兔多克隆抗体
  • 货号：
    CSB-PA009825
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P48742
  • 基因名：
    LHX1
  • 别名：
    hLim-1 antibody; Homeo box protein Lim 1 antibody; Homeo box protein Lim1 antibody; Homeobox protein Lim 1 antibody; Homeobox protein Lim-1 antibody; Homeobox protein Lim1 antibody; LHX 1 antibody; LHX1 antibody; LHX1_HUMAN antibody; LIM 1 antibody; LIM homeo box 1 antibody; LIM homeo box protein 1 antibody; LIM homeobox 1 antibody; LIM homeobox protein 1 antibody; LIM-1 antibody; LIM/homeobox protein Lhx 1 antibody; LIM/homeobox protein Lhx1 antibody; MGC126723 antibody; MGC138141 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human LHX1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
  • 基因功能参考文献：
    1. Report novel missense mutation in LHX1 in congenital absence of the uterus and vagina which could change the transcriptional activity of LHX1 and its effect on the regulation of the downstream target gene GSC. PMID: 28061432
    2. Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B, and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%. PMID: 28600106
    3. Data have identified TBX6 as a new gene associated with Mullerian aplasia. The results also support the relevance of LHX1 and CNVs in the development of this congenital malformation. PMID: 23954021
    4. study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients PMID: 22740494
    5. Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. PMID: 22875024
    6. Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling PMID: 22231913
    7. Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities. PMID: 22217964
    8. Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity. PMID: 21778788
    9. findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma PMID: 21132009
    10. Lim1 (also known as Lhx1) gene consists of a DNA-binding homeodomain and 2 cysteine-rich LIM domains, which may participate in protein to protein interactions, and encodes a transcription factor. PMID: 19849868

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines.
  • 数据库链接：

    HGNC: 6593

    OMIM: 601999

    KEGG: hsa:3975

    STRING: 9606.ENSP00000254457

    UniGene: Hs.443727