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KAP123 Antibody

  • 中文名称：
    KAP123兔多克隆抗体
  • 货号：
    CSB-PA336672XA01SVG
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: KAP123 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 28 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) KAP123 Polyclonal antibody
  • Uniprot No.：
    P40069
  • 基因名：
    KAP123
  • 别名：
    Importin subunit beta-4 (Importin-123) (Karyopherin subunit beta-4) (Karyopherin-123) (Ran-binding protein YRB4) KAP123 YRB4 YER110C
  • 宿主：
    Rabbit
  • 反应种属：
    Saccharomyces cerevisiae (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (Baker's yeast) KAP123 protein (859-1110aa)
  • 免疫原种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins. Required for import of the ribosomal assembly factor NMD3. May be involved in nuclear transport of YAP1. Mediates the nuclear import of histones H3 and H4. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 基因功能参考文献：
    1. The karyopherin Kap123 binds to a nuclear localization sequence next to this amphipathic alpha-helix and prevents unspecific tethering of Nbp1 to membranes. PMID: 21785410
    2. Slt2, the mitogen-activated protein kinase of the protein kinase C cell integrity pathway, is constitutively activated in the absence of Kap123, which is consistent with the existence of cell integrity defects. PMID: 19930464
    3. A role for the karyopherin Kap123p in microtubule stability is reported. PMID: 19761543
    4. The Kap123p specifically binds to histones H2A and H2B. PMID: 15679097
  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nuclear pore complex.
  • 蛋白家族：
    Importin beta family
  • 数据库链接：

    KEGG: sce:YER110C

    STRING: 4932.YER110C