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HTRA4 Antibody

  • 中文名称：
    HTRA4兔多克隆抗体
  • 货号：
    CSB-PA010904GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P83105
  • 基因名：
    HTRA4
  • 别名：
    FLJ90724 antibody; High temperature requirement protean A4 antibody; High-temperature requirement factor A4 antibody; HTRA 4 antibody; HtrA serine peptidase 4 antibody; HTRA4 antibody; HTRA4_HUMAN antibody; Probable serine protease HTRA4 antibody; Serine protease HTRA4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HTRA4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine protease.
  • 基因功能参考文献：
    1. the aberrant expression of HTRA1 or HTRA4 may be involved in the onset of preeclampsia, and increased HTRA1 or HTRA4 expression may affect trophoblast functions. PMID: 30015931
    2. GATA3 knockdown elevated HtrA4 expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion. PMID: 26899996
    3. HtrA4 represents a novel placenta-specific serine protease that is altered specifically in early-onset preeclampsia with potential causal roles in endothelial dysfunction and disease development. PMID: 25946029
    4. Conditioned media from these two cell lines after decidualization treatment suppress HtrA4-expressing JAR cell invasion in an HtrA1- or HtrA3-dependent manner. PMID: 25002585
    5. Data suggest that increased HtrA4 (and HtrA1) in placenta tissues may be involved in onset of pre-eclampsia; elevated level of HtrA4 (but not HtrA1) in sera has potential as biomarker for pre-eclampsia. PMID: 22964307
    6. study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia PMID: 22778138
    7. FLJ90724 or HTRA4 is a member of the HtrA family of proteases PMID: 12408815

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1C family
  • 数据库链接：

    HGNC: 26909

    OMIM: 610700

    KEGG: hsa:203100

    STRING: 9606.ENSP00000305919

    UniGene: Hs.661014